Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 3/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.36 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.36 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | GRM5 | P41594 | 1/20 | 0.35 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.35 |
| ▸ | FAAH | O00519 | 3/20 | 0.35 |
| ▸ | ATR | Q13535 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 2/20 | 0.34 |
| ▸ | BCR | P11274 | 2/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | FYN | P06241 | 2/20 | 0.33 |
| ▸ | KARS1 | Q15046 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19670598 | 1.00 | GSK3B (0.36) | GSK3BDYRK1ACDK5CDK5R1SMN1; SMN2 | |
| SCHEMBL17618545 | 0.86 | CNR1 (0.36) | GSK3BDYRK1ASMN1; SMN2GRM5SIRT2 | |
| SCHEMBL17618629 | 0.86 | CNR1 (0.36) | GSK3BDYRK1ASMN1; SMN2GRM5SIRT2 | |
| SCHEMBL16754469 | 0.84 | SMN1; SMN2 (0.39) | GSK3BDYRK1ASMN1; SMN2SIRT2FAAH | |
| SCHEMBL17624235 | 0.84 | FAAH (0.40) | SMN1; SMN2FAAHHDAC8CNR1FYN | |
| SCHEMBL19670448 | 0.84 | FAAH (0.40) | SMN1; SMN2FAAHHDAC8CNR1FYN | |
| SCHEMBL19365767 | 0.81 | SIRT2 (0.36) | GSK3BDYRK1ASMN1; SMN2GRM5SIRT2 | |
| SCHEMBL16785510 | 0.81 | BRAF (0.41) | GSK3BDYRK1ASMN1; SMN2HTR2CCNR1 | |
| SCHEMBL17624674 | 0.81 | BRAF (0.41) | GSK3BDYRK1ASMN1; SMN2HTR2CCNR1 | |
| SCHEMBL19670235 | 0.79 | GSK3B (0.36) | GSK3BDYRK1ASIRT2FAAHABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9765075-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-09-19 | — | — | US | disclosed |
| US-20160083386-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC | 2016-03-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160083386-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | SIRT1, SIRT3, SIRT2 | GSK3B 2465/4885DYRK1A 2415/4885CDK5 497/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.