Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 6/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 6/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | KARS1 | Q15046 | 1/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | KMO | O15229 | 1/20 | 0.35 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.35 |
| ▸ | FAAH | O00519 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19670370 | 0.90 | P2RX7 (0.38) | KMT2AMEN1ABL1MAPT | |
| SCHEMBL19365761 | 0.89 | MAPT (0.37) | GSK3BKDM4ERAB9AKMT2AMEN1 | |
| SCHEMBL19365409 | 0.88 | RAB9A (0.41) | GSK3BDYRK1ARAB9AKMT2AMEN1 | |
| SCHEMBL19365410 | 0.88 | RAB9A (0.41) | GSK3BDYRK1ARAB9AKMT2AMEN1 | |
| SCHEMBL19670491 | 0.86 | FAAH (0.38) | GSK3BDYRK1AKMT2AKARS1FAAH | |
| SCHEMBL17618678 | 0.84 | KMO (0.36) | GSK3BDYRK1AKDM4ERAB9AKMT2A | |
| SCHEMBL19364899 | 0.83 | ALOX15 (0.38) | GSK3BDYRK1AABL1MAPTCHEK1 | |
| SCHEMBL19365401 | 0.82 | MALT1 (0.40) | GSK3BDYRK1ARAB9AKMOFAAH | |
| SCHEMBL19365400 | 0.82 | MALT1 (0.40) | GSK3BDYRK1ARAB9AKMOFAAH | |
| SCHEMBL19706063 | 0.79 | SIRT2 (0.37) | GSK3BDYRK1AKDM4ERAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |