Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 8/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 8/20 | 0.56 |
| ▸ | HDAC3 | O15379 | 7/20 | 0.56 |
| ▸ | HDAC4 | P56524 | 7/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 7/20 | 0.56 |
| ▸ | HDAC7 | Q8WUI4 | 7/20 | 0.56 |
| ▸ | HDAC2 | Q92769 | 7/20 | 0.56 |
| ▸ | HDAC10 | Q969S8 | 7/20 | 0.56 |
| ▸ | HDAC11 | Q96DB2 | 7/20 | 0.56 |
| ▸ | HDAC9 | Q9UKV0 | 7/20 | 0.56 |
| ▸ | HDAC5 | Q9UQL6 | 7/20 | 0.56 |
| ▸ | SRC | P12931 | 1/20 | 0.52 |
| ▸ | TEK | Q02763 | 4/20 | 0.44 |
| ▸ | KDR | P35968 | 4/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30737158 | 0.89 | HDAC3 (0.45) | HDAC8HDAC6HDAC3HDAC4HDAC1 | |
| SCHEMBL16775813 | 0.88 | UCHL5 (0.44) | HDAC8HDAC6HDAC3HDAC4HDAC1 | |
| SCHEMBL17273760 | 0.88 | HDAC3 (0.51) | HDAC8HDAC6HDAC3HDAC4HDAC1 | |
| SCHEMBL17618318 | 0.87 | HDAC3 (0.43) | HDAC8HDAC6HDAC3HDAC4HDAC1 | |
| SCHEMBL18379926 | 0.78 | HDAC3 (0.53) | HDAC8HDAC6HDAC3HDAC4HDAC1 | |
| SCHEMBL11967048 | 0.76 | PSEN1 (0.61) | — | |
| SCHEMBL15775419 | 0.76 | ALDH1A1 (0.43) | POLBATM | |
| SCHEMBL15775751 | 0.75 | ALDH1A1 (0.43) | — | |
| SCHEMBL17998120 | 0.74 | MAPT (0.46) | HDAC8HDAC6HDAC3HDAC4HDAC1 | |
| SCHEMBL16775729 | 0.74 | HDAC8 (0.39) | HDAC8HDAC6HDAC3HDAC4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2997029-B1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC (US) | 2019-01-09 | — | — | EP | disclosed |
| US-20170355697-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC | 2017-12-14 | — | — | US | disclosed |
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |
| US-9765075-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-09-19 | — | — | US | disclosed |
| US-20160083386-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC | 2016-03-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160083386-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | SIRT1, SIRT3, SIRT2 | HDAC8 89/4885HDAC6 30/4885HDAC3 86/4885 |
| US-20170355697-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | SIRT1, SIRT3, SIRT2 | HDAC8 110/4885HDAC6 25/4885HDAC3 70/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.