Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 4/20 | 0.69 |
| ▸ | SCN5A | Q14524 | 4/20 | 0.69 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.39 |
| ▸ | SLC18A2 | Q05940 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2625038 | 1.00 | KCNA5 (0.69) | KCNA5SCN5ASIGMAR1SLC18A2HRH3 | |
| SCHEMBL12204055 | 1.00 | KCNA5 (0.69) | KCNA5SCN5ASIGMAR1SLC18A2HRH3 | |
| SCHEMBL1762344 | 1.00 | KCNA5 (0.69) | KCNA5SCN5ASIGMAR1SLC18A2HRH3 | |
| SCHEMBL6807137 | 0.82 | KCNA5 (1.00) | KCNA5SCN5ASIGMAR1SLC18A2KDM4E | |
| SCHEMBL2624914 | 0.82 | KCNA5 (1.00) | KCNA5SCN5ASIGMAR1SLC18A2KDM4E | |
| SCHEMBL12391697 | 0.82 | KCNA5 (1.00) | KCNA5SCN5ASIGMAR1SLC18A2KDM4E | |
| SCHEMBL12203898 | 0.81 | KCNA5 (0.82) | KCNA5SCN5ASIGMAR1SLC18A2HRH3 | |
| SCHEMBL2625053 | 0.81 | KCNA5 (0.82) | KCNA5SCN5ASIGMAR1SLC18A2HRH3 | |
| SCHEMBL8194037 | 0.81 | KCNA5 (0.47) | KCNA5SCN5ASIGMAR1ALDH1A1TSHR | |
| SCHEMBL6445899 | 0.80 | KCNA5 (0.95) | KCNA5SCN5ASIGMAR1SLC18A2SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8188140-B2 | Uses of ion channel modulating compounds | CARDIOME PHARMA CORP. | 2012-05-29 | — | — | US | disclosed |
| US-20110118329-A1 | USES OF ION CHANNEL MODULATING COMPOUNDS | CARDIOME PHARMA CORP. (CA) | 2011-05-19 | — | — | US | disclosed |
| US-7820712-B2 | Uses of ion channel modulating compounds | CARDIOME PHARMA CORP. (CA) | 2010-10-26 | — | — | US | disclosed |
| US-20090041841-A1 | CONTROLLED RELEASE TABLET FORMULATIONS FOR THE PREVENTION OF ARRHYTHMIAS | CARDIOME PHARMA CORP. (CA) | 2009-02-12 | — | — | US | disclosed |
| US-20080188547-A1 | USES OF ION CHANNEL MODULATING COMPOUNDS | CARDIOME PHARMA CORP. (CA) | 2008-08-07 | — | — | US | disclosed |
| US-7345086-B2 | Uses of ion channel modulating compounds | CARDIOME PHARMA CORP. (CA) | 2008-03-18 | — | — | US | disclosed |
| US-20050026993-A1 | Uses of ion channel modulating compounds | CORREVIO CANADA CORP. (CA) | 2005-02-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090041841-A1 | CONTROLLED RELEASE TABLET FORMULATIONS FOR THE PREVENTION OF ARRHYTHMIAS | KCNN3, KCNN2, KCNN1 | KCNA5 78/4885SCN5A 59/4885SIGMAR1 3103/4885 |
| US-20050026993-A1 | Uses of ion channel modulating compounds | KCNN1, KCNN2, KCNN3 | KCNA5 48/4885SCN5A 49/4885SIGMAR1 3877/4885 |
| US-20110118329-A1 | USES OF ION CHANNEL MODULATING COMPOUNDS | KCNN1, KCNN2, KCNN3 | KCNA5 48/4885SCN5A 49/4885SIGMAR1 3877/4885 |
| US-20080188547-A1 | USES OF ION CHANNEL MODULATING COMPOUNDS | KCNN1, KCNN2, KCNN3 | KCNA5 48/4885SCN5A 49/4885SIGMAR1 3877/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.