Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NUDT14 | O95848 | 2/20 | 0.48 |
| ▸ | NUDT5 | Q9UKK9 | 2/20 | 0.48 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.48 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.48 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.48 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.48 |
| ▸ | PRKDC | P78527 | 2/20 | 0.48 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.44 |
| ▸ | SGK1 | O00141 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.44 |
| ▸ | EIF4E | P06730 | 1/20 | 0.44 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.44 |
| ▸ | MTOR | P42345 | 1/20 | 0.44 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | BRSK2 | Q8IWQ3 | 1/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.44 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.44 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14617841 | 0.88 | BTK (0.52) | NUDT14NUDT5PIK3CDPIK3CAPIK3CB | |
| SCHEMBL200349 | 0.88 | NUDT14 (0.62) | NUDT14NUDT5PIK3CDPIK3CAPIK3CB | |
| SCHEMBL12808147 | 0.86 | BTK (0.50) | NUDT14NUDT5PIK3CDPIK3CAPIK3CB | |
| SCHEMBL12713498 | 0.86 | PIK3CD (0.50) | NUDT14NUDT5PIK3CDPIK3CAPIK3CB | |
| Hydrochloric Acid SCHEMBL29439185 | 0.86 | NUDT14 (0.61) | NUDT14NUDT5PIK3CDPIK3CAPIK3CB | |
| SCHEMBL18235468 | 0.86 | KDR (0.49) | NUDT14NUDT5PIK3CDPIK3CAPIK3CB | |
| SCHEMBL30415900 | 0.86 | FYN (0.47) | NUDT14NUDT5PIK3CDPIK3CAPIK3CB | |
| SCHEMBL22692848 | 0.86 | FYN (0.47) | NUDT14NUDT5PIK3CDPIK3CAPIK3CB | |
| SCHEMBL30416234 | 0.86 | PIK3CA (0.45) | NUDT14NUDT5PIK3CDPIK3CAPIK3CB | |
| SCHEMBL22243273 | 0.82 | PIK3CD (0.41) | NUDT14NUDT5PIK3CDPIK3CAPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12384786-B2 | Cyclic molecules as Bruton's tyrosine kinase inhibitor | MINGHUI PHARMACEUTICAL SHANGHAI LTD (CN) | 2025-08-12 | — | — | US | disclosed |
| CN-111454268-B | Cyclic molecules as inhibitors of bruton's tyrosine kinase | 明慧医药（上海）有限公司 | 2023-09-08 | — | — | CN | disclosed |
| CN-116589465-A | Cyclic molecules as inhibitors of bruton's tyrosine kinase | 明慧医药（上海）有限公司 | 2023-08-15 | — | — | CN | disclosed |
| CN-116134028-A | Compound capable of degrading BTK kinase, preparation method and pharmaceutical application thereof | 四川海思科制药有限公司 | 2023-05-16 | — | — | CN | disclosed |
| CN-113710671-B | Cyclic molecules as inhibitors of bruton's tyrosine kinase | 明慧医药（上海）有限公司 | 2023-04-28 | — | — | CN | disclosed |
| US-20220081445-A1 | CYCLIC MOLECULES AS BRUTON'S TYROSINE KINASE INHIBITOR | MINGHUI PHARMACEUTICAL SHANGHAI LTD (CN) | 2022-03-17 | — | — | US | disclosed |
| EP-3912980-A1 | CYCLIC MOLECULES AS BRUTON'S TYROSINE KINASE INHIBITOR | Minghui Pharmaceutical (Shanghai) Limited (CN) | 2021-11-24 | — | — | EP | disclosed |
| EP-3912980-A1 | CYCLIC MOLECULES AS BRUTON'S TYROSINE KINASE INHIBITOR | Minghui Pharmaceutical (Shanghai) Limited (CN) | 2021-11-24 | — | — | EP | disclosed |
| WO-2020147798-A1 | CYCLIC MOLECULES AS BRUTON'S TYROSINE KINASE INHIBITOR | 明慧医药（上海）有限公司 | 2020-07-23 | — | — | WO | disclosed |
| US-9694011-B2 | Substituted pyrazolopyrimidines as kinases inhibitors | JIANGSU MEDOLUTION LTD (CN) | 2017-07-04 | — | — | US | disclosed |
| US-9694011-B2 | Substituted pyrazolopyrimidines as kinases inhibitors | JIANGSU MEDOLUTION LTD (CN) | 2017-07-04 | — | — | US | disclosed |
| US-9694011-B2 | Substituted pyrazolopyrimidines as kinases inhibitors | JIANGSU MEDOLUTION LTD (CN) | 2017-07-04 | — | — | US | disclosed |
| US-20160120868-A1 | SUBSTITUTED PYRAZOLOPYRIMIDINES AS KINASES INHIBITORS | JIANGSU MEDOLUTION LTD. (CN) | 2016-05-05 | — | — | US | disclosed |
| US-20160120868-A1 | SUBSTITUTED PYRAZOLOPYRIMIDINES AS KINASES INHIBITORS | JIANGSU MEDOLUTION LTD. (CN) | 2016-05-05 | — | — | US | disclosed |
| US-20160120868-A1 | SUBSTITUTED PYRAZOLOPYRIMIDINES AS KINASES INHIBITORS | JIANGSU MEDOLUTION LTD. (CN) | 2016-05-05 | — | — | US | disclosed |
| EP-2999702-A1 | SUBSTITUTED PYRAZOLOPYRIMIDINES AS KINASES INHIBITORS | Jiangsu Medolution Ltd. (CN) | 2016-03-30 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160120868-A1 | SUBSTITUTED PYRAZOLOPYRIMIDINES AS KINASES INHIBITORS | BTK, LCK, ABL1 | NUDT14 1946/4885NUDT5 1199/4885PIK3CD 224/4885 |
| US-12384786-B2 | Cyclic molecules as Bruton's tyrosine kinase inhibitor | ABL1, BTK, LYN | NUDT14 2861/4885NUDT5 2600/4885PIK3CD 355/4885 |
| US-20220081445-A1 | CYCLIC MOLECULES AS BRUTON'S TYROSINE KINASE INHIBITOR | ABL1, BTK, LYN | NUDT14 2861/4885NUDT5 2600/4885PIK3CD 355/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.