Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 5/20 | 0.49 |
| ▸ | TEK | Q02763 | 2/20 | 0.49 |
| ▸ | LCK | P06239 | 1/20 | 0.49 |
| ▸ | SRC | P12931 | 3/20 | 0.49 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.49 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.49 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.49 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.49 |
| ▸ | PRKDC | P78527 | 2/20 | 0.49 |
| ▸ | ABL1 | P00519 | 2/20 | 0.49 |
| ▸ | EGFR | P00533 | 2/20 | 0.49 |
| ▸ | HCK | P08631 | 1/20 | 0.49 |
| ▸ | MTOR | P42345 | 1/20 | 0.49 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.49 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.49 |
| ▸ | NUDT14 | O95848 | 2/20 | 0.48 |
| ▸ | NUDT5 | Q9UKK9 | 2/20 | 0.48 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL149528 | 0.96 | KDR (0.52) | KDRTEKLCKSRCPIK3CD | |
| SCHEMBL12713498 | 0.89 | PIK3CD (0.50) | KDRTEKLCKSRCPIK3CD | |
| SCHEMBL200349 | 0.88 | NUDT14 (0.62) | KDRTEKLCKSRCPIK3CD | |
| Hydrochloric Acid SCHEMBL29439185 | 0.86 | NUDT14 (0.61) | KDRTEKLCKSRCPIK3CD | |
| SCHEMBL12808147 | 0.86 | BTK (0.50) | KDRTEKLCKSRCPIK3CD | |
| SCHEMBL17626654 | 0.86 | NUDT14 (0.48) | LCKPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL19414290 | 0.84 | SRC (0.57) | KDRLCKSRCPIK3CDPIK3CA | |
| SCHEMBL30416234 | 0.83 | PIK3CA (0.45) | KDRTEKLCKSRCPIK3CD | |
| SCHEMBL22243273 | 0.82 | PIK3CD (0.41) | KDRTEKLCKSRCPIK3CD | |
| SCHEMBL19414293 | 0.82 | ALDH1A1 (0.50) | KDRLCKSRCPIK3CDPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116134028-A | Compound capable of degrading BTK kinase, preparation method and pharmaceutical application thereof | 四川海思科制药有限公司 | 2023-05-16 | — | — | CN | disclosed |
| WO-2016180334-A1 | DUAL-SITE IRREVERSIBLE BRUTON'S TYROSINE KINASE INHIBITOR, COMPOSITION AND APPLICATION THEREFOF | 杭州和正医药有限公司 | 2016-11-17 | — | — | WO | disclosed |