Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 3/20 | 0.47 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.47 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.47 |
| ▸ | FLT3 | P36888 | 2/20 | 0.37 |
| ▸ | GCGR | P47871 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | SRPK2 | P78362 | 1/20 | 0.34 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.34 |
| ▸ | PDE5A | O76074 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17629912 | 0.85 | CYP11B2 (0.47) | CYP11B1CYP11B2CYP19A1FLT3KDM4E | |
| SCHEMBL17629919 | 0.78 | KDM1A (0.37) | CYP11B1CYP11B2MAOBERBB2AHR | |
| SCHEMBL17630089 | 0.75 | CYP11B1 (0.41) | CYP11B1CYP11B2CYP19A1PKN1PKN2 | |
| SCHEMBL17630001 | 0.75 | CYP11B1 (0.41) | CYP11B1CYP11B2CYP19A1PKN1PKN2 | |
| SCHEMBL17629922 | 0.74 | KDM1A (0.41) | ERBB2 | |
| SCHEMBL17630007 | 0.72 | HRH2 (0.36) | CYP11B1CYP11B2CYP19A1MAOBKDM4E | |
| SCHEMBL17630189 | 0.71 | ALDH1A1 (0.41) | CYP11B2KDM4ETSHRPOLBAHR | |
| SCHEMBL17630076 | 0.71 | HRH2 (0.35) | CYP11B1CYP11B2CYP19A1KDM4ELMNA | |
| SCHEMBL8377267 | 0.70 | CYP19A1 (0.43) | CYP11B1CYP11B2CYP19A1MAOBTSHR | |
| SCHEMBL29337092 | 0.70 | MAOB (0.44) | CYP19A1MAOBTSHRMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016046782-A1 | IMIDAZOLE BIARYL COMPOUNDS AS S-NITROSOGLUTATHIONE REDUCTASE INHIBITORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2016-03-31 | — | — | WO | disclosed |