Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.39 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.39 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.39 |
| ▸ | GRM5 | P41594 | 12/20 | 0.37 |
| ▸ | UCHL1 | P09936 | 2/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | PARK7 | Q99497 | 1/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.33 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17632318 | 0.88 | GRM5 (0.41) | TLR8TLR7GRM5UCHL1MAPK14 | |
| SCHEMBL17631750 | 0.87 | GRM5 (0.38) | GRM5UCHL1MAPK14SIGMAR1PARK7 | |
| SCHEMBL17632276 | 0.86 | F10 (0.41) | NPC1RAB9A | |
| SCHEMBL17632462 | 0.85 | FASN (0.35) | GRM5UCHL1MAPK14SIGMAR1PARK7 | |
| SCHEMBL17631972 | 0.81 | GRM5 (0.51) | GRM5PARK7 | |
| SCHEMBL17632465 | 0.81 | GRM5 (0.43) | GRM5NPC1RAB9A | |
| SCHEMBL17632587 | 0.81 | NPC1 (0.40) | GRM5NPC1RAB9A | |
| SCHEMBL17631678 | 0.79 | GRM5 (0.41) | GRM5ALDH1A1 | |
| SCHEMBL17631931 | 0.79 | GRM5 (0.43) | GRM5NPC1RAB9A | |
| SCHEMBL17631978 | 0.79 | GRM5 (0.41) | GRM5ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3197883-A1 | NOVEL COMPOUNDS | Mission Therapeutics Limited (GB) | 2017-08-02 | — | — | EP | claimed |
| WO-2016046530-A1 | NOVEL COMPOUNDS | MISSION THERAPEUTICS LTD (GB) | 2016-03-31 | — | — | WO | claimed |
| EP-3197883-A1 | NOVEL COMPOUNDS | Mission Therapeutics Limited (GB) | 2017-08-02 | — | — | EP | disclosed |
| WO-2016046530-A1 | NOVEL COMPOUNDS | MISSION THERAPEUTICS LTD (GB) | 2016-03-31 | — | — | WO | disclosed |