Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | SLC9A1 | P19634 | 11/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 7/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 6/20 | 0.52 |
| ▸ | RBP4 | P02753 | 4/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.48 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.48 |
| ▸ | HTR2A | P28223 | 1/20 | 0.48 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.48 |
| ▸ | SLC9A2 | Q9UBY0 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1764080 | 0.90 | RBP4 (0.61) | SMN1; SMN2NPC1RAB9ASLC9A1CYP2C19 | |
| SCHEMBL7838902 | 0.81 | SMN1; SMN2 (0.54) | SMN1; SMN2NPC1RAB9ACYP2C19CYP2C9 | |
| SCHEMBL19404809 | 0.81 | RBP4 (0.59) | SMN1; SMN2NPC1RAB9ACYP2C19RBP4 | |
| SCHEMBL1763737 | 0.81 | SLC9A1 (0.54) | SLC9A1CYP2C19CYP2C9CYP3A4ADRA1D | |
| SCHEMBL6825112 | 0.80 | SMN1; SMN2 (0.51) | SMN1; SMN2NPC1RAB9ACYP2C19CYP2C9 | |
| SCHEMBL1763271 | 0.78 | RBP4 (0.72) | SMN1; SMN2RAB9ASLC9A1CYP2C19CYP2C9 | |
| SCHEMBL8316925 | 0.77 | SMN1; SMN2 (0.61) | SMN1; SMN2NPC1RAB9ACYP2C19CYP2C9 | |
| SCHEMBL7666258 | 0.77 | SMN1; SMN2 (0.55) | SMN1; SMN2NPC1RAB9ACYP2C19CYP2C9 | |
| SCHEMBL31188362 | 0.76 | SLC9A1 (0.50) | SLC9A1CYP2C19CYP2C9RBP4CYP3A4 | |
| SCHEMBL1763934 | 0.76 | SLC9A1 (0.54) | SLC9A1CYP2C19CYP2C9RBP4CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110118262-A1 | Pyrrolidinyl and Piperidinyl Compounds Useful as NHE-1 Inhibitiors | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-05-19 | — | — | US | disclosed |
| EP-2321274-A1 | PYRROLIDINYL AND PIPERIDINYL COMPOUNDS USEFUL AS NHE-1 INHIBITORS | Boehringer Ingelheim International GmbH (DE) | 2011-05-18 | — | — | EP | disclosed |
| WO-2010005783-A1 | PYRROLIDINYL AND PIPERIDINYL COMPOUNDS USEFUL AS NHE-1 INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-01-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110118262-A1 | Pyrrolidinyl and Piperidinyl Compounds Useful as NHE-1 Inhibitiors | NHERF1, SLC9A1, SLC9A5 | SMN1; SMN2 4454/4885NPC1 236/4885RAB9A 698/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.