Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX3 | P56373 | 5/20 | 0.57 |
| ▸ | P2RX1 | P51575 | 4/20 | 0.57 |
| ▸ | P2RX2 | Q9UBL9 | 3/20 | 0.57 |
| ▸ | P2RX4 | Q99571 | 4/20 | 0.55 |
| ▸ | P2RY1 | P47900 | 9/20 | 0.54 |
| ▸ | P2RY2 | P41231 | 4/20 | 0.54 |
| ▸ | SRC | P12931 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | RNASEL | Q05823 | 1/20 | 0.53 |
| ▸ | P2RY11 | Q96G91 | 1/20 | 0.52 |
| ▸ | PARG | Q86W56 | 1/20 | 0.52 |
| ▸ | MACROD2 | A1Z1Q3 | 1/20 | 0.51 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.51 |
| ▸ | MACROD1 | Q9BQ69 | 1/20 | 0.51 |
| ▸ | TRPM2 | O94759 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30023659 | 1.00 | P2RX3 (0.57) | P2RX3P2RX1P2RX2P2RX4P2RY1 | |
| SCHEMBL29937508 | 0.92 | P2RY1 (0.58) | P2RY1P2RY2SRCSMN1; SMN2RNASEL | |
| SCHEMBL7743363 | 0.89 | P2RX1 (0.56) | P2RX3P2RX1P2RX2P2RX4P2RY1 | |
| SCHEMBL30633441 | 0.89 | P2RX1 (0.56) | P2RX3P2RX1P2RX2P2RX4P2RY1 | |
| SCHEMBL596738 | 0.87 | P2RX1 (0.57) | P2RX3P2RX1P2RX2P2RX4P2RY1 | |
| SCHEMBL29725493 | 0.85 | P2RX1 (0.53) | P2RX3P2RX1P2RX2P2RX4P2RY1 | |
| SCHEMBL28794808 | 0.85 | P2RX1 (0.53) | P2RX3P2RX1P2RX2P2RX4P2RY1 | |
| SCHEMBL11031781 | 0.84 | P2RX1 (0.62) | P2RX3P2RX1P2RX2P2RX4P2RY1 | |
| SCHEMBL28390621 | 0.83 | P2RX1 (0.61) | P2RX3P2RX1P2RX2P2RX4P2RY1 | |
| SCHEMBL30777206 | 0.83 | P2RX1 (0.61) | P2RX3P2RX1P2RX2P2RX4P2RY1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170275672-A1 | CHEMICALLY MODIFIED LIGASE COFACTORS, DONORS AND ACCEPTORS | TRILINK BIOTECHNOLOGIES, INC. (US) | 2017-09-28 | — | — | US | disclosed |
| US-9631227-B2 | Chemically modified ligase cofactors, donors and acceptors | TRILINK BIOTECHNOLOGIES, INC. (US) | 2017-04-25 | — | — | US | disclosed |
| US-20140323354-A1 | Chemically Modified Ligase Cofactors, Donors and Acceptors | TRILINK BIOTECHNOLOGIES, INC. (US) | 2014-10-30 | — | — | US | disclosed |
| EP-2451980-B1 | CHEMICALLY MODIFIED LIGASE COFACTORS, DONORS AND ACCEPTORS | TRILINK BIOTECHNOLOGIES (US) | 2014-05-21 | — | — | EP | disclosed |
| US-8728725-B2 | Chemically modified ligase cofactors, donors and acceptors | TRILINK BIOTECHNOLOGIES (US) | 2014-05-20 | — | — | US | disclosed |
| US-8614312-B2 | Method for preparing nucleotides and related analogues by synthesis on soluble substrate, and biological tools thus prepared | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2013-12-24 | — | — | US | disclosed |
| CN-102083998-A | High throughput nucleic acid sequencing by expansion | STRATOS GENOMICS INC | 2011-06-01 | — | — | CN | disclosed |
| US-20110118454-A1 | METHOD FOR PREPARING NUCLEOTIDES AND RELATED ANALOGUES BY SYNTHESIS ON SOLUBLE SUBSTRATE, AND BIOLOGICAL TOOLS THUS PREPARED | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2011-05-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110118454-A1 | METHOD FOR PREPARING NUCLEOTIDES AND RELATED ANALOGUES BY SYNTHESIS ON SOLUBLE SUBSTRATE, AND BIOLOGICAL TOOLS THUS PREPARED | PNP, NUDT1, DUT | P2RX3 539/4885P2RX1 447/4885P2RX2 598/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.