Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.36 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.36 |
| ▸ | IKBKB | O14920 | 1/20 | 0.35 |
| ▸ | CDK9 | P50750 | 1/20 | 0.35 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.33 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.33 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.33 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.32 |
| ▸ | PARP14 | Q460N5 | 2/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17632525 | 0.86 | CHEK1 (0.41) | USP30LIMK1CDK9UCHL1CHEK1 | |
| SCHEMBL17632937 | 0.84 | CHEK1 (0.37) | USP30CDK9UCHL1CHEK1CHRM3 | |
| SCHEMBL17631847 | 0.84 | USP30 (0.37) | USP30IKBKBCDK9UCHL1CHEK1 | |
| SCHEMBL17631806 | 0.84 | KDM1A (0.40) | USP30UCHL1CHEK1 | |
| SCHEMBL17632036 | 0.82 | USP30 (0.50) | USP30UCHL1CHEK1 | |
| SCHEMBL17631780 | 0.79 | USP30 (0.39) | USP30CDK9UCHL1ALDH1A1 | |
| SCHEMBL17631685 | 0.78 | DYRK1B (0.44) | USP30UCHL1CHEK1ALDH1A1 | |
| SCHEMBL17631604 | 0.78 | DYRK1B (0.44) | USP30UCHL1CHEK1ALDH1A1 | |
| SCHEMBL17631562 | 0.77 | CDK9 (0.34) | USP30CDK9UCHL1 | |
| SCHEMBL17632487 | 0.77 | USP30 (0.41) | USP30UCHL1CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3197883-A1 | NOVEL COMPOUNDS | Mission Therapeutics Limited (GB) | 2017-08-02 | — | — | EP | claimed |
| WO-2016046530-A1 | NOVEL COMPOUNDS | MISSION THERAPEUTICS LTD (GB) | 2016-03-31 | — | — | WO | claimed |
| EP-3197883-A1 | NOVEL COMPOUNDS | Mission Therapeutics Limited (GB) | 2017-08-02 | — | — | EP | disclosed |
| WO-2016046530-A1 | NOVEL COMPOUNDS | MISSION THERAPEUTICS LTD (GB) | 2016-03-31 | — | — | WO | disclosed |