Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 1/20 | 0.41 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.40 |
| ▸ | USP30 | Q70CQ3 | 4/20 | 0.38 |
| ▸ | CDK9 | P50750 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 8/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 8/20 | 0.36 |
| ▸ | UCHL1 | P09936 | 2/20 | 0.36 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.35 |
| ▸ | MBTPS1 | Q14703 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17632937 | 0.90 | CHEK1 (0.37) | CHEK1CHRNB2CHRNA4USP30CDK9 | |
| SCHEMBL17631847 | 0.90 | USP30 (0.37) | CHEK1CHRNB2CHRNA4USP30CDK9 | |
| SCHEMBL17632036 | 0.88 | USP30 (0.50) | CHEK1USP30UCHL1KCNH2 | |
| SCHEMBL17632174 | 0.86 | USP30 (0.36) | CHEK1USP30CDK9UCHL1LIMK1 | |
| SCHEMBL17631780 | 0.85 | USP30 (0.39) | USP30CDK9SLC6A2SLC6A4UCHL1 | |
| SCHEMBL17632491 | 0.84 | CHEK1 (0.42) | CHEK1USP30SLC6A2SLC6A4UCHL1 | |
| SCHEMBL17632150 | 0.84 | USP30 (0.43) | CHEK1USP30SLC6A2SLC6A4UCHL1 | |
| SCHEMBL17631604 | 0.83 | DYRK1B (0.44) | CHEK1USP30UCHL1CYP3A4 | |
| SCHEMBL17631685 | 0.83 | DYRK1B (0.44) | CHEK1USP30UCHL1CYP3A4 | |
| SCHEMBL17631562 | 0.82 | CDK9 (0.34) | USP30CDK9UCHL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3197883-A1 | NOVEL COMPOUNDS | Mission Therapeutics Limited (GB) | 2017-08-02 | — | — | EP | claimed |
| WO-2016046530-A1 | NOVEL COMPOUNDS | MISSION THERAPEUTICS LTD (GB) | 2016-03-31 | — | — | WO | claimed |