Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 1/20 | 0.58 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.58 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.56 |
| ▸ | DPP4 | P27487 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | SLC28A1 | O00337 | 1/20 | 0.56 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.56 |
| ▸ | SLC28A2 | O43868 | 1/20 | 0.56 |
| ▸ | GAPDH | P04406 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.56 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.56 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.56 |
| ▸ | STAT6 | P42226 | 1/20 | 0.56 |
| ▸ | PI4KA | P42356 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.56 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.56 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29987989 | 0.91 | PRMT5 (0.56) | PRMT5WDR77ADORA3DPP4MEN1 | |
| SCHEMBL15203726 | 0.89 | ADORA3 (0.51) | PRMT5WDR77ADORA3DPP4MEN1 | |
| SCHEMBL3831030 | 0.89 | AHCY (0.58) | PRMT5WDR77ADORA3DPP4MEN1 | |
| SCHEMBL12170660 | 0.87 | AHCY (0.49) | ADORA3DPP4MEN1SLC28A1MAP3K7 | |
| SCHEMBL18948229 | 0.87 | AHCY (0.49) | ADORA3DPP4MEN1SLC28A1MAP3K7 | |
| SCHEMBL12060715 | 0.87 | PRMT5 (0.56) | PRMT5WDR77ADORA3DPP4MEN1 | |
| SCHEMBL12386685 | 0.85 | PRMT5 (0.56) | PRMT5WDR77ADORA3DPP4MEN1 | |
| SCHEMBL18073288 | 0.85 | PRMT5 (0.56) | PRMT5WDR77ADORA3DPP4MEN1 | |
| SCHEMBL561654 | 0.82 | PRMT5 (0.64) | PRMT5WDR77ADORA3DPP4MEN1 | |
| SCHEMBL561515 | 0.82 | PRMT5 (0.64) | PRMT5WDR77ADORA3DPP4MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3197457-B1 | 4'-VINYL SUBSTITUTED NUCLEOSIDE DERIVATIVES AS INHIBITORS OF RESPIRATORY SYNCYTIAL VIRUS RNA REPLICATION | RIBOSCIENCE LLC (US) | 2022-11-09 | — | — | EP | claimed |
| EP-3197457-B1 | 4'-VINYL SUBSTITUTED NUCLEOSIDE DERIVATIVES AS INHIBITORS OF RESPIRATORY SYNCYTIAL VIRUS RNA REPLICATION | RIBOSCIENCE LLC (US) | 2022-11-09 | — | — | EP | disclosed |
| US-10358458-B2 | 4′-vinyl substituted nucleoside derivatives as inhibitors of respiratory syncytial virus RNA replication | RIBOSCIENCE LLC (US) | 2019-07-23 | — | — | US | disclosed |
| US-10358458-B2 | 4′-vinyl substituted nucleoside derivatives as inhibitors of respiratory syncytial virus RNA replication | RIBOSCIENCE LLC (US) | 2019-07-23 | — | — | US | disclosed |
| EP-3197457-A1 | 4'-VINYL SUBSTITUTED NUCLEOSIDE DERIVATIVES AS INHIBITORS OF RESPIRATORY SYNCYTIAL VIRUS RNA REPLICATION | Riboscience LLC (US) | 2017-08-02 | — | — | EP | disclosed |
| US-20160264611-A1 | 4'-VINYL SUBSTITUTED NUCLEOSIDE DERIVATIVES AS INHIBITORS OF RESPIRATORY SYNCYTIAL VIRUS RNA REPLICATION | RIBOSCIENCE LLC | 2016-09-15 | — | — | US | disclosed |
| US-20160264611-A1 | 4'-VINYL SUBSTITUTED NUCLEOSIDE DERIVATIVES AS INHIBITORS OF RESPIRATORY SYNCYTIAL VIRUS RNA REPLICATION | RIBOSCIENCE LLC | 2016-09-15 | — | — | US | disclosed |
| US-20160264611-A1 | 4'-VINYL SUBSTITUTED NUCLEOSIDE DERIVATIVES AS INHIBITORS OF RESPIRATORY SYNCYTIAL VIRUS RNA REPLICATION | RIBOSCIENCE LLC | 2016-09-15 | — | — | US | disclosed |
| WO-2016049415-A1 | 4'-VINYL SUBSTITUTED NUCLEOSIDE DERIVATIVES AS INHIBITORS OF RESPIRATORY SYNCYTIAL VIRUS RNA REPLICATION | RIBOSCIENCE LLC (US) | 2016-03-31 | — | — | WO | disclosed |
| WO-2016049415-A1 | 4'-VINYL SUBSTITUTED NUCLEOSIDE DERIVATIVES AS INHIBITORS OF RESPIRATORY SYNCYTIAL VIRUS RNA REPLICATION | RIBOSCIENCE LLC (US) | 2016-03-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160264611-A1 | 4'-VINYL SUBSTITUTED NUCLEOSIDE DERIVATIVES AS INHIBITORS OF RESPIRATORY SYNCYTIAL VIRUS RNA REPLICATION | NSUN2, RNMT, RRM2 | PRMT5 366/4885WDR77 1357/4885ADORA3 739/4885 |
| US-10358458-B2 | 4′-vinyl substituted nucleoside derivatives as inhibitors of respiratory syncytial virus RNA replication | NSUN2, RNMT, SNRPF | PRMT5 347/4885WDR77 1421/4885ADORA3 733/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.