Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | CASP6 | P55212 | 1/20 | 0.49 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.47 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MET | P08581 | 1/20 | 0.46 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.46 |
| ▸ | F10 | P00742 | 2/20 | 0.44 |
| ▸ | F2 | P00734 | 1/20 | 0.44 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.44 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 4/20 | 0.42 |
| ▸ | ITK | Q08881 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31334040 | 0.78 | CDK8 (0.50) | L3MBTL1BTK | |
| SCHEMBL2365692 | 0.77 | L3MBTL1 (0.56) | L3MBTL1NR1H2NR1H3METALK | |
| SCHEMBL12519774 | 0.76 | MAPK1 (0.54) | ALDH1A1MAPTKDM4EEGFRITK | |
| SCHEMBL13166463 | 0.76 | SYK (0.51) | POLBCASP6ALDH1A1PIN1GAA | |
| SCHEMBL30672854 | 0.76 | POLB (0.53) | POLBCASP6ALDH1A1PIN1GAA | |
| SCHEMBL16706312 | 0.76 | POLB (0.53) | POLBCASP6ALDH1A1PIN1GAA | |
| SCHEMBL16370708 | 0.75 | EGFR (0.73) | EGFRITKBTK | |
| SCHEMBL4911339 | 0.75 | L3MBTL1 (0.54) | L3MBTL1NR1H2NR1H3METALK | |
| SCHEMBL25113772 | 0.74 | POLB (0.50) | POLBCASP6ALDH1A1PIN1GAA | |
| SCHEMBL10515255 | 0.74 | RAB9A (0.65) | L3MBTL1POLBALDH1A1MRGPRX4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9296737-B2 | Substituted 2,4-diaminopyrimidines as kinase inhibitors | CELGENE AVILOMICS RESEARCH, INC. (US) | 2016-03-29 | — | — | US | disclosed |
| US-9296737-B2 | Substituted 2,4-diaminopyrimidines as kinase inhibitors | CELGENE AVILOMICS RESEARCH, INC. (US) | 2016-03-29 | — | — | US | disclosed |