Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RBP4 | P02753 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | SLC9A1 | P19634 | 17/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 7/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 6/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.44 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
| ▸ | SLC9A2 | Q9UBY0 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1763569 | 1.00 | RBP4 (0.56) | RBP4RAB9ASLC9A1CYP2C9CYP2C19 | |
| SCHEMBL1763299 | 1.00 | RBP4 (0.56) | RBP4RAB9ASLC9A1CYP2C9CYP2C19 | |
| SCHEMBL1763378 | 0.95 | RBP4 (0.63) | RBP4SLC9A1CYP2C9CYP2C19CYP3A4 | |
| SCHEMBL1763953 | 0.85 | SLC9A1 (0.61) | RAB9ASLC9A1CYP2C9CYP2C19CYP3A4 | |
| SCHEMBL1764074 | 0.85 | SLC9A1 (0.61) | RAB9ASLC9A1CYP2C9CYP2C19CYP3A4 | |
| SCHEMBL1763612 | 0.85 | SLC9A1 (0.61) | RAB9ASLC9A1CYP2C9CYP2C19CYP3A4 | |
| SCHEMBL1763744 | 0.83 | SLC9A1 (0.64) | SLC9A1CYP2C9CYP2C19CYP3A4CYP2D6 | |
| SCHEMBL1764039 | 0.81 | SLC9A1 (0.58) | RBP4SLC9A1CYP2C9CYP2C19CYP3A4 | |
| SCHEMBL1763318 | 0.81 | SLC9A1 (0.56) | SLC9A1CYP2C9CYP2C19CYP3A4CYP2D6 | |
| SCHEMBL1763943 | 0.81 | SLC9A1 (0.69) | RBP4SLC9A1CYP2C9CYP2C19CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110118262-A1 | Pyrrolidinyl and Piperidinyl Compounds Useful as NHE-1 Inhibitiors | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-05-19 | — | — | US | disclosed |
| US-20110118262-A1 | Pyrrolidinyl and Piperidinyl Compounds Useful as NHE-1 Inhibitiors | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-05-19 | — | — | US | disclosed |
| US-20110118262-A1 | Pyrrolidinyl and Piperidinyl Compounds Useful as NHE-1 Inhibitiors | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-05-19 | — | — | US | disclosed |
| WO-2010005783-A1 | PYRROLIDINYL AND PIPERIDINYL COMPOUNDS USEFUL AS NHE-1 INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-01-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110118262-A1 | Pyrrolidinyl and Piperidinyl Compounds Useful as NHE-1 Inhibitiors | NHERF1, SLC9A1, SLC9A5 | RBP4 4521/4885RAB9A 698/4885SLC9A1 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.