Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.53 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.51 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.51 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.51 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | TNKS | O95271 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | GABRP | O00591 | 2/20 | 0.47 |
| ▸ | GABRD | O14764 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10357156 | 0.93 | NPSR1 (0.53) | NPSR1RXFP1PIK3CDPIK3CAPIK3CB | |
| SCHEMBL31511489 | 0.93 | NPSR1 (0.53) | NPSR1RXFP1PIK3CDPIK3CAPIK3CB | |
| SCHEMBL16797962 | 0.87 | NPSR1 (0.64) | NPSR1RXFP1L3MBTL1KDM4EALDH1A1 | |
| SCHEMBL16801876 | 0.87 | NPC1 (0.64) | NPSR1RXFP1PIK3CDPIK3CAPIK3CB | |
| SCHEMBL16925949 | 0.81 | CYP1A2 (0.43) | RXFP1PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL29709713 | 0.80 | KMT2A (0.62) | NPSR1RXFP1L3MBTL1KDM4EALDH1A1 | |
| SCHEMBL304367 | 0.80 | KMT2A (0.62) | NPSR1RXFP1L3MBTL1KDM4EALDH1A1 | |
| SCHEMBL29416517 | 0.80 | KMT2A (0.62) | NPSR1RXFP1L3MBTL1KDM4EALDH1A1 | |
| SCHEMBL205534 | 0.79 | PDE2A (0.56) | NPSR1RXFP1L3MBTL1KDM4EALDH1A1 | |
| SCHEMBL26768424 | 0.79 | CDC25A (0.48) | NPSR1RXFP1L3MBTL1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11024815-B2 | Metal complexes | MERCK PATENT GMBH (DE) | 2021-06-01 | — | — | US | disclosed |
| EP-3197887-B1 | HETEROCYCLIC COMPOUNDS WITH BENZO[C]COUMARIN-STRUCTURES | MERCK PATENT GMBH (DE) | 2020-09-23 | — | — | EP | disclosed |
| US-10377766-B2 | Heterocyclic compounds with benzo(c)coumarin-structures | MERCK PATENT GMBH (DE) | 2019-08-13 | — | — | US | disclosed |
| EP-3254317-B1 | METAL COMPLEXES | MERCK PATENT GMBH (DE) | 2019-07-31 | — | — | EP | disclosed |
| US-20180026209-A1 | Metal Complexes | MERCK PATENT GMBH (DE) | 2018-01-25 | — | — | US | disclosed |
| US-20180026209-A1 | Metal Complexes | MERCK PATENT GMBH (DE) | 2018-01-25 | — | — | US | disclosed |
| US-20170298077-A1 | HETEROCYCLIC COMPOUNDS WITH BENZO(C)COUMARIN-STRUCTURES | MERCK PATENT GMBH (DE) | 2017-10-19 | — | — | US | disclosed |
| US-20170298077-A1 | HETEROCYCLIC COMPOUNDS WITH BENZO(C)COUMARIN-STRUCTURES | MERCK PATENT GMBH (DE) | 2017-10-19 | — | — | US | disclosed |
| WO-2016124304-A1 | METAL COMPLEXES | MERCK PATENT GMBH (DE) | 2016-08-11 | — | — | WO | disclosed |
| WO-2016045769-A1 | HETEROCYCLIC COMPOUNDS WITH BENZO[C]COUMARIN-STRUCTURES | MERCK PATENT GMBH (DE) | 2016-03-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170298077-A1 | HETEROCYCLIC COMPOUNDS WITH BENZO(C)COUMARIN-STRUCTURES | NISCH, SIRT3, NQO1 | NPSR1 2494/4885RXFP1 4685/4885PIK3CD 3719/4885 |
| US-11024815-B2 | Metal complexes | EXOC4, EXOC3, TIMCC | NPSR1 3462/4885RXFP1 4808/4885PIK3CD 2059/4885 |
| US-10377766-B2 | Heterocyclic compounds with benzo(c)coumarin-structures | NISCH, SIRT3, NQO1 | NPSR1 2494/4885RXFP1 4685/4885PIK3CD 3719/4885 |
| US-20180026209-A1 | Metal Complexes | AP3M1, AP2M1, SOD1 | NPSR1 3181/4885RXFP1 4865/4885PIK3CD 2933/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.