Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A11 | P48066 | 1/20 | 0.52 |
| ▸ | S100A4 | P26447 | 1/20 | 0.52 |
| ▸ | PTPRC | P08575 | 2/20 | 0.50 |
| ▸ | BCL2 | P10415 | 2/20 | 0.45 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | BCR | P11274 | 1/20 | 0.43 |
| ▸ | PGR | P06401 | 2/20 | 0.42 |
| ▸ | ERN1 | O75460 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21580251 | 0.90 | SLC6A11 (0.61) | SLC6A11PTPRCKCNH2PGRERN1 | |
| SCHEMBL30512416 | 0.90 | SLC6A11 (0.61) | SLC6A11PTPRCKCNH2PGRERN1 | |
| SCHEMBL27554974 | 0.83 | SLC6A11 (0.58) | SLC6A11PTPRCBCL2MCL1KCNH2 | |
| SCHEMBL12737886 | 0.76 | SLC6A11 (0.50) | SLC6A11KCNH2PGRERN1PDK2 | |
| SCHEMBL29390614 | 0.75 | S100A4 (0.90) | S100A4PTPRCBCL2MCL1CYP1A2 | |
| SCHEMBL39700 | 0.75 | S100A4 (0.90) | S100A4PTPRCBCL2MCL1CYP1A2 | |
| SCHEMBL16852596 | 0.75 | PTPRC (0.63) | S100A4PTPRCBCL2MCL1ALDH1A1 | |
| SCHEMBL15553849 | 0.75 | PTPRC (0.63) | S100A4PTPRCBCL2MCL1ALDH1A1 | |
| SCHEMBL1310724 | 0.73 | ABL1 (0.60) | KCNH2ABL1BCRPGRERN1 | |
| SCHEMBL27875479 | 0.72 | MAPT (0.41) | PTPRCKDM4EALDH1A1HPGDMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3197887-B1 | HETEROCYCLIC COMPOUNDS WITH BENZO[C]COUMARIN-STRUCTURES | MERCK PATENT GMBH (DE) | 2020-09-23 | — | — | EP | disclosed |
| US-10377766-B2 | Heterocyclic compounds with benzo(c)coumarin-structures | MERCK PATENT GMBH (DE) | 2019-08-13 | — | — | US | disclosed |
| US-20170298077-A1 | HETEROCYCLIC COMPOUNDS WITH BENZO(C)COUMARIN-STRUCTURES | MERCK PATENT GMBH (DE) | 2017-10-19 | — | — | US | disclosed |
| US-20170298077-A1 | HETEROCYCLIC COMPOUNDS WITH BENZO(C)COUMARIN-STRUCTURES | MERCK PATENT GMBH (DE) | 2017-10-19 | — | — | US | disclosed |
| WO-2016045769-A1 | HETEROCYCLIC COMPOUNDS WITH BENZO[C]COUMARIN-STRUCTURES | MERCK PATENT GMBH (DE) | 2016-03-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170298077-A1 | HETEROCYCLIC COMPOUNDS WITH BENZO(C)COUMARIN-STRUCTURES | NISCH, SIRT3, NQO1 | SLC6A11 3933/4885S100A4 3734/4885PTPRC 1986/4885 |
| US-10377766-B2 | Heterocyclic compounds with benzo(c)coumarin-structures | NISCH, SIRT3, NQO1 | SLC6A11 3933/4885S100A4 3734/4885PTPRC 1986/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.