Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 1/20 | 0.44 |
| ▸ | ACACB | O00763 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.31 |
| ▸ | GRM5 | P41594 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5238211 | 0.79 | GBA1 (0.55) | GBA1ACACBKDM4ENPC1ALDH1A1 | |
| SCHEMBL7258115 | 0.78 | PTPN11 (0.36) | GBA1NPC1MAPK1SMN1; SMN2RAB9A | |
| SCHEMBL27101554 | 0.77 | POLB (0.46) | GBA1KDM4EALDH1A1MAPK1 | |
| SCHEMBL3616165 | 0.77 | ESR1 (0.36) | GBA1KDM4ENPC1MAPK1RAB9A | |
| SCHEMBL629463 | 0.75 | ALDH1A1 (0.48) | GBA1KDM4EALDH1A1MAPK1SMN1; SMN2 | |
| SCHEMBL12888687 | 0.75 | CYP2D6 (0.34) | ACACBKDM4EALDH1A1 | |
| SCHEMBL13271174 | 0.75 | GBA1 (0.33) | GBA1 | |
| SCHEMBL20772888 | 0.74 | DAO (0.36) | GBA1ACACBPDE10A | |
| SCHEMBL3606370 | 0.74 | ACACB (0.41) | ACACBALDH1A1MAPK1 | |
| SCHEMBL20394335 | 0.72 | LMNA (0.48) | GBA1KDM4ENPC1ALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3201196-A1 | FUSED PENTACYCLIC IMIDAZOLE DERIVATIVES | UCB Biopharma SPRL (BE) | 2017-08-09 | — | — | EP | disclosed |
| WO-2016050975-A1 | FUSED PENTACYCLIC IMIDAZOLE DERIVATIVES | UCB BIOPHARMA SPRL (BE) | 2016-04-07 | — | — | WO | disclosed |