Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | KMO | O15229 | 1/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 5/20 | 0.33 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.33 |
| ▸ | GPR52 | Q9Y2T5 | 3/20 | 0.33 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.33 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.33 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.33 |
| ▸ | RAF1 | P04049 | 2/20 | 0.32 |
| ▸ | KDM1A | O60341 | 1/20 | 0.32 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.32 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.32 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17655369 | 0.94 | GRIN1 (0.34) | CA2CA9TRPV1 | |
| SCHEMBL17655423 | 0.92 | CA2 (0.37) | CA2CA9KMOTRPV1ADAM17 | |
| SCHEMBL12653833 | 0.91 | CA2 (0.38) | CA2CA9KMOTRPV1ADAM17 | |
| SCHEMBL17655393 | 0.91 | GPR52 (0.37) | CA2CA9KMOTRPV1GPR52 | |
| SCHEMBL12654665 | 0.88 | PRMT5 (0.39) | CA2CA9KMOGPR52PRMT5 | |
| SCHEMBL12654540 | 0.88 | TRPV1 (0.34) | CA2CA9KMOTRPV1GPR52 | |
| SCHEMBL17655335 | 0.87 | FGFR4 (0.43) | CA2CA9KMOPRMT5WDR77 | |
| SCHEMBL12654532 | 0.86 | PRMT5 (0.39) | CA2CA9TRPV1PRMT5WDR77 | |
| SCHEMBL17655422 | 0.85 | KIF18A (0.36) | CA2CA9KMOTRPV1GPR52 | |
| SCHEMBL17655352 | 0.85 | FGFR4 (0.43) | CA2CA9KMOADAM17PRMT5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9556201-B2 | Bicyclic pyridines and analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-01-31 | — | — | US | disclosed |
| US-9556201-B2 | Bicyclic pyridines and analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-01-31 | — | — | US | disclosed |
| EP-2493888-B1 | BICYCLIC PYRIDINES AND ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC (US) | 2016-04-06 | — | — | EP | disclosed |
| WO-2011059839-A1 | BICYCLIC PYRIDINES AND ANALOGS AS SIRTUIN MODULATORS | SIRTRIS PHARMACEUTICALS, INC. (US) | 2011-05-19 | — | — | WO | disclosed |