Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.35 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | MGAM | O43451 | 1/20 | 0.32 |
| ▸ | SI | P14410 | 1/20 | 0.32 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8132962 | 0.79 | MAPT (0.36) | MAPTALDH1A1KDM4EPDCD1CD274 | |
| SCHEMBL17616016 | 0.78 | CA2 (0.39) | MAPTALDH1A1KDM4EPDCD1CD274 | |
| SCHEMBL2361510 | 0.77 | ALDH1A1 (0.35) | ALDH1A1PDCD1CD274PDE4ALMNA | |
| SCHEMBL14405259 | 0.77 | ALDH1A1 (0.36) | MAPTALDH1A1KDM4ELMNASMN1; SMN2 | |
| SCHEMBL16077689 | 0.75 | MAPT (0.44) | MAPTALDH1A1KDM4ELMNATDP1 | |
| SCHEMBL11129066 | 0.74 | MAPT (0.38) | MAPTALDH1A1KDM4EPDCD1CD274 | |
| SCHEMBL13027122 | 0.74 | PDCD1 (0.36) | MAPTALDH1A1KDM4EPDCD1CD274 | |
| SCHEMBL698659 | 0.73 | KDM1A (0.46) | KDM4EPDCD1CD274PDE4APDE4B | |
| SCHEMBL9410517 | 0.73 | ALDH1A1 (0.45) | MAPTALDH1A1KDM4ELMNASMN1; SMN2 | |
| SCHEMBL4897798 | 0.72 | PDCD1 (0.41) | MAPTALDH1A1KDM4EPDCD1CD274 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2402349-B1 | TRICYCLIC PYRAZOLOPYRIMIDINE DERIVATIVES | DAIICHI SANKYO CO LTD (JP) | 2016-04-06 | — | — | EP | disclosed |