Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 7/20 | 0.51 |
| ▸ | NPC1 | O15118 | 6/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | GAA | P10253 | 4/20 | 0.51 |
| ▸ | TP53 | P04637 | 3/20 | 0.51 |
| ▸ | HPGD | P15428 | 3/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | GLA | P06280 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | CASP3 | P42574 | 1/20 | 0.51 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.51 |
| ▸ | RELA | Q04206 | 1/20 | 0.51 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.51 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12798227 | 0.95 | RAB9A (0.51) | RAB9ANPC1SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL12171998 | 0.86 | RAB9A (0.57) | RAB9ANPC1SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL1505232 | 0.83 | RAB9A (0.51) | RAB9ANPC1SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL12171780 | 0.82 | NPC1 (0.60) | RAB9ANPC1SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL12171787 | 0.81 | VCP (0.52) | RAB9ANPC1SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL12171870 | 0.81 | PTPN1 (0.60) | RAB9ANPC1SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL19199453 | 0.79 | ALOX15 (0.60) | RAB9ANPC1SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL12797818 | 0.79 | RAB9A (0.58) | RAB9ANPC1SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL12796869 | 0.79 | NPC1 (0.56) | RAB9ANPC1SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL12171401 | 0.79 | RAB9A (0.54) | RAB9ANPC1SMN1; SMN2KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1815206-B1 | COMPOUNDS FOR NONSENSE SUPPRESSION, AND METHODS FOR THEIR USE | PTC THERAPEUTICS INC (US) | 2016-04-06 | — | — | EP | disclosed |