Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 8/20 | 0.31 |
| ▸ | PTGES | O14684 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17656783 | 0.78 | CHRM1 (0.48) | P2RX7CHRM1 | |
| SCHEMBL12803022 | 0.74 | CHRM1 (0.55) | CHRM1 | |
| SCHEMBL2226225 | 0.74 | APOBEC3A (0.38) | — | |
| SCHEMBL6891774 | 0.72 | ADORA2A (0.33) | P2RX7ADORA2ACHRM1 | |
| SCHEMBL12802494 | 0.71 | CHRM1 (0.43) | CHRM1 | |
| SCHEMBL12802497 | 0.71 | CHRM1 (0.43) | CHRM1 | |
| SCHEMBL6892942 | 0.69 | CHRM1 (0.49) | CHRM1 | |
| SCHEMBL12803393 | 0.69 | ADORA2A (0.32) | ADORA2A | |
| SCHEMBL17585463 | 0.68 | CHRM1 (0.48) | CHRM1 | |
| SCHEMBL6890674 | 0.66 | CHRM1 (0.49) | CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2512243-A1 | QUINOLINE AMIDE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | Merck Sharp & Dohme Corp. (US) | 2012-10-24 | — | — | EP | claimed |
| WO-2011084368-A1 | QUINOLINE AMIDE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK SHARP & DOHME CORP. (US) | 2011-07-14 | — | — | WO | claimed |