Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | BCL2 | P10415 | 1/20 | 0.32 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17718419 | 0.83 | LMNA (0.36) | LMNAUSP2TDP1BCL2MCL1 | |
| SCHEMBL17657308 | 0.82 | MEN1 (0.34) | LMNAUSP2BCL2MCL1MEN1 | |
| SCHEMBL13718825 | 0.75 | PIK3CD (0.42) | — | |
| SCHEMBL17657299 | 0.72 | MAPT (0.36) | LMNAUSP2BCL2MCL1MEN1 | |
| SCHEMBL17718413 | 0.70 | CA1 (0.48) | KMT2APOLBALDH1A1 | |
| SCHEMBL13717611 | 0.70 | AR (0.38) | LMNAUSP2TDP1MEN1KMT2A | |
| SCHEMBL20878586 | 0.67 | THRB (0.38) | TDP1MEN1KMT2APOLBALDH1A1 | |
| SCHEMBL13826314 | 0.66 | KDM4E (0.41) | LMNAUSP2TDP1BCL2MCL1 | |
| SCHEMBL13825904 | 0.66 | KDM4E (0.41) | LMNAUSP2TDP1BCL2MCL1 | |
| SCHEMBL13718190 | 0.66 | KDM4E (0.41) | LMNAUSP2TDP1BCL2MCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016054491-A1 | HETEROCYCLIC COMPOUNDS AND USES THEREOF | INFINITY PHARMACEUTICALS, INC. (US) | 2016-04-07 | — | — | WO | disclosed |