Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 6/20 | 0.34 |
| ▸ | TP53 | P04637 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | HPGD | P15428 | 3/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31395666 | 0.81 | MAPT (0.39) | MAPTPTGS1PTGS2CA1CA2 | |
| SCHEMBL17718332 | 0.80 | TTR (0.44) | MAPTPTGS1PTGS2CA1CA2 | |
| SCHEMBL13717954 | 0.80 | AR (0.48) | MAPTPTGS1PTGS2CA1CA2 | |
| SCHEMBL17657298 | 0.80 | TTR (0.36) | MAPTCYP2C9HPGDHSD17B10MEN1 | |
| SCHEMBL17657308 | 0.77 | MEN1 (0.34) | MAPTCA1CA2TP53KDM4E | |
| SCHEMBL8733 | 0.76 | CA1 (0.59) | MAPTCA1CA2CYP2C9TP53 | |
| SCHEMBL13545619 | 0.75 | MAPT (0.54) | MAPTPTGS1PTGS2CA1CA2 | |
| SCHEMBL17657286 | 0.72 | LMNA (0.34) | MEN1KMT2ALMNAUSP2HSP90AA1 | |
| SCHEMBL9078888 | 0.71 | CYP3A4 (0.67) | MAPTCA1CA2CYP2C9TP53 | |
| SCHEMBL18709047 | 0.70 | ALDH1A1 (0.39) | MAPTPTGS1PTGS2CYP2C9TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016054491-A1 | HETEROCYCLIC COMPOUNDS AND USES THEREOF | INFINITY PHARMACEUTICALS, INC. (US) | 2016-04-07 | — | — | WO | disclosed |