Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 2/20 | 0.40 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.40 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.40 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.36 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.36 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.34 |
| ▸ | BTK | Q06187 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19686591 | 1.00 | HSD11B1 (0.40) | HSD11B1CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL8299600 | 0.89 | CYP1A2 (0.42) | HSD11B1CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL14290751 | 0.85 | CHRNB2 (0.48) | HSD11B1CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL18035981 | 0.82 | MEN1 (0.34) | HSD11B1KCNQ3KCNQ2BTKALDH1A1 | |
| SCHEMBL17660647 | 0.82 | PDE4B (0.35) | HSD11B1CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL25094200 | 0.82 | PDE4B (0.35) | HSD11B1CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL18035978 | 0.82 | MEN1 (0.34) | HSD11B1KCNQ3KCNQ2BTKALDH1A1 | |
| SCHEMBL12448268 | 0.82 | PDE4B (0.35) | HSD11B1CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL15802795 | 0.82 | HPGD (0.47) | PDE4BEPHX1PIK3CDALDH1A1 | |
| SCHEMBL3332529 | 0.82 | HPGD (0.47) | PDE4BEPHX1PIK3CDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10040781-B2 | Tank-binding kinase inhibitor compounds | GILEAD SCIENCES, INC. (US) | 2018-08-07 | — | — | US | disclosed |
| US-20160096827-A1 | TANK-BINDING KINASE INHIBITOR COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2016-04-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10040781-B2 | Tank-binding kinase inhibitor compounds | TBKBP1, TNKS1BP1, TNKS | HSD11B1 3493/4885CHRNB2 4074/4885CHRNA4 4694/4885 |
| US-20160096827-A1 | TANK-BINDING KINASE INHIBITOR COMPOUNDS | TBKBP1, TNKS1BP1, TNKS | HSD11B1 3493/4885CHRNB2 4074/4885CHRNA4 4694/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.