SCHEMBL1766396

SCHEMBL1766396

CNc1cccc(C(=O)Nc2c(Br)cc(C(F)(C(F)(F)F)C(F)(F)F)cc2C(F)(F)F)c1F

nearest known ligand 0.43

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 2/20 0.43
RXFP1 Q9HBX9 8/20 0.40
PTGES O14684 4/20 0.37
BRAF P15056 1/20 0.37
CTSS P25774 1/20 0.36
LCK P06239 1/20 0.35
KDR P35968 1/20 0.35
MAPK14 Q16539 1/20 0.35
TAS2R14 Q9NYV8 3/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29634361 1.00 SMN1; SMN2 (0.43) SMN1; SMN2RXFP1PTGESBRAFCTSS
SCHEMBL23048342 0.93 SMN1; SMN2 (0.37) SMN1; SMN2RXFP1PTGESBRAFTAS2R14
SCHEMBL2240566 0.92 RXFP1 (0.41) SMN1; SMN2RXFP1
SCHEMBL18156542 0.91 SMN1; SMN2 (0.42) SMN1; SMN2RXFP1BRAFCTSSLCK
SCHEMBL29161174 0.91 SMN1; SMN2 (0.44) SMN1; SMN2RXFP1PTGESCTSSTAS2R14
SCHEMBL12440630 0.89 RXFP1 (0.41) SMN1; SMN2RXFP1PTGESBRAFCTSS
SCHEMBL28629194 0.89 SMN1; SMN2 (0.41) SMN1; SMN2RXFP1PTGESCTSS
SCHEMBL23059627 0.88 SMN1; SMN2 (0.39) SMN1; SMN2RXFP1PTGESCTSS
SCHEMBL1766615 0.88 SMN1; SMN2 (0.46) SMN1; SMN2RXFP1PTGES
SCHEMBL1766517 0.88 RXFP1 (0.40) SMN1; SMN2RXFP1PTGESBRAFCTSS

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 50 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11891371-B2 Piperonylic acid derivative and preparation and application thereof Shenyang Sinochem Agrochemicals R&D Co., LTD (CN) 2024-02-06 US disclosed
WO-2023051261-A1 IMINE COMPOUND AND USE THEREOF 沈阳中化农药化工研发有限公司 2023-04-06 WO disclosed
CN-115872901-A Imine compound and application thereof 沈阳中化农药化工研发有限公司 2023-03-31 CN disclosed
CN-109206397-B Piperamic acid derivative and preparation and application thereof 沈阳中化农药化工研发有限公司 2022-06-07 CN disclosed
CN-114573547-A Amide derivative, preparation method and application thereof 东莞市东阳光农药研发有限公司 2022-06-03 CN disclosed
EP-3205642-B1 ANILINE INTERMEDIATE FOR THE PREPARATION OF AN AMIDE DERIVATIVE, PEST CONTROL AGENT CONTAINING THE AMIDE DERIVATIVE. MITSUI CHEMICALS AGRO INC (JP) 2022-03-23 EP disclosed
EP-3647305-B1 PIPERIC ACID DERIVATIVE AND PREPARATION AND APPLICATION THEREOF SHENYANG SINOCHEM AGROCHEMICALS R & D CO LTD (CN) 2022-02-23 EP disclosed
EP-3647305-B1 PIPERIC ACID DERIVATIVE AND PREPARATION AND APPLICATION THEREOF SHENYANG SINOCHEM AGROCHEMICALS R & D CO LTD (CN) 2022-02-23 EP disclosed
EP-3316692-B1 PESTICIDAL COMPOSITIONS COMPRISING A TRIAZOLE COMPOUND BASF AGRO BV (NL) 2021-03-17 EP disclosed
EP-3081552-B1 PEST CONTROL AGENT CONTAINING AN AMIDE DERIVATIVE AND USE OF THE PEST CONTROL AGENT MITSUI CHEMICALS AGRO INC (JP) 2021-03-03 EP disclosed
EP-2529620-A1 COMPOSITION FOR CONTROL OF ANIMAL PARASITES, AND METHOD FOR CONTROL OF ANIMAL PARASITES Mitsui Chemicals Agro, Inc. (JP) 2012-12-05 EP disclosed
CN-102740695-A Composition for exterminating animal parasites and method for exterminating animal parasites MITSUI CHEMICALS AGRO INC 2012-10-17 CN disclosed
US-20110201687-A1 AMIDE DERIVATIVE, PEST CONTROL AGENT CONTAINING THE AMIDE DERIVATIVE, AND USE OF THE AMIDE DERIVATIVE MITSUI CHEMICALS AGRO, INC. (JP) 2011-08-18 US disclosed
US-20110201687-A1 AMIDE DERIVATIVE, PEST CONTROL AGENT CONTAINING THE AMIDE DERIVATIVE, AND USE OF THE AMIDE DERIVATIVE MITSUI CHEMICALS AGRO, INC. (JP) 2011-08-18 US disclosed
CN-102119143-A Amide derivative, pest control agent containing the same, and method of using the pest control agent MITSUI CHEMICALS AGRO INC 2011-07-06 CN disclosed
CN-102112437-A Amide derivative, pest control agent containing same, and pest control method MITSUI CHEMICALS AGRO INC 2011-06-29 CN disclosed
US-20110136878-A1 AMIDE DERIVATIVE, PEST CONTROL AGENT CONTAINING THE AMIDE DERIVATIVE, AND PEST CONTROLLING METHOD Mitsui Chemicals Agro., Inc. (JP) 2011-06-09 US disclosed
US-20110136878-A1 AMIDE DERIVATIVE, PEST CONTROL AGENT CONTAINING THE AMIDE DERIVATIVE, AND PEST CONTROLLING METHOD Mitsui Chemicals Agro., Inc. (JP) 2011-06-09 US disclosed
EP-2325165-A1 AMIDE DERIVATIVE, PEST CONTROL AGENT CONTAINING THE AMIDE DERIVATIVE AND PEST CONTROLLING METHOD Mitsui Chemicals Agro, Inc. (JP) 2011-05-25 EP disclosed
EP-2319830-A1 AMIDE DERIVATIVE, PEST CONTROL AGENT CONTAINING THE AMIDE DERIVATIVE AND USE OF THE PEST CONTROL AGENT Mitsui Chemicals Agro, Inc. (JP) 2011-05-11 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110136878-A1 AMIDE DERIVATIVE, PEST CONTROL AGENT CONTAINING THE AMIDE DERIVATIVE, AND PEST CONTROLLING METHOD L3MBTL1, L3MBTL4, L3MBTL3 SMN1; SMN2 3830/4885RXFP1 1891/4885PTGES 1884/4885
US-11891371-B2 Piperonylic acid derivative and preparation and application thereof CYP51A1, DDT, PIR SMN1; SMN2 2918/4885RXFP1 4519/4885PTGES 1705/4885
US-20110201687-A1 AMIDE DERIVATIVE, PEST CONTROL AGENT CONTAINING THE AMIDE DERIVATIVE, AND USE OF THE AMIDE DERIVATIVE H1-2, H1-4, H1-0 SMN1; SMN2 4436/4885RXFP1 2628/4885PTGES 2222/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.