Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | RECQL | P46063 | 1/20 | 0.53 |
| ▸ | P4HB | P07237 | 1/20 | 0.51 |
| ▸ | MAOB | P27338 | 4/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | FBP1 | P09467 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | CA12 | O43570 | 1/20 | 0.49 |
| ▸ | CA1 | P00915 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
| ▸ | CA9 | Q16790 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17664301 | 0.83 | KDM4E (0.57) | MEN1LMNAHSP90AA1MAPTPKM | |
| SCHEMBL17664299 | 0.81 | HTT (0.60) | MEN1LMNAHSP90AA1MAPTPKM | |
| SCHEMBL17664313 | 0.80 | MAPT (0.64) | MEN1LMNAHSP90AA1MAPTPKM | |
| SCHEMBL1124017 | 0.80 | LMNA (0.62) | MEN1LMNAHSP90AA1MAPTPKM | |
| SCHEMBL1124018 | 0.80 | LMNA (0.62) | MEN1LMNAHSP90AA1MAPTPKM | |
| SCHEMBL17664233 | 0.78 | MLYCD (0.53) | MEN1LMNAHSP90AA1MAPTPKM | |
| SCHEMBL3167843 | 0.77 | RECQL (0.57) | MEN1LMNAHSP90AA1MAPTPKM | |
| SCHEMBL17664337 | 0.77 | LMNA (0.51) | MEN1LMNAHSP90AA1MAPTPKM | |
| SCHEMBL17664237 | 0.76 | CNR1 (0.58) | MEN1LMNAHSP90AA1MAPTPKM | |
| SCHEMBL10586039 | 0.76 | LMNA (0.55) | MEN1LMNAHSP90AA1MAPTPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016049774-A1 | UREA AND BIS-UREA BASED COMPOUNDS AND ANALOGUES THEREOF USEFUL IN THE TREATMENT OF ANDROGEN RECEPTOR MEDIATED DISEASES OR DISORDERS | THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY (CA) | 2016-04-07 | — | — | WO | disclosed |