Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDO2 | P48775 | 2/20 | 0.52 |
| ▸ | IDO1 | P14902 | 3/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.34 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.34 |
| ▸ | CFTR | P13569 | 1/20 | 0.33 |
| ▸ | PRKCI | P41743 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | DRD3 | P35462 | 1/20 | 0.32 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.31 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.31 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.31 |
| ▸ | FYN | P06241 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17665682 | 0.86 | TDO2 (0.56) | TDO2IDO1CYP11B1CYP11B2CYP3A4 | |
| SCHEMBL17665465 | 0.84 | TDO2 (0.43) | TDO2IDO1ABCB1 | |
| SCHEMBL17665343 | 0.79 | TDO2 (0.45) | TDO2IDO1 | |
| SCHEMBL17665333 | 0.79 | TDO2 (0.45) | TDO2IDO1CYP3A4 | |
| SCHEMBL17665688 | 0.78 | TDO2 (0.58) | TDO2IDO1CYP3A4 | |
| SCHEMBL17651963 | 0.77 | TDO2 (0.49) | TDO2IDO1CYP11B1CYP11B2CFTR | |
| SCHEMBL17665340 | 0.73 | TDO2 (0.55) | TDO2IDO1CYP3A4 | |
| SCHEMBL17651983 | 0.70 | TDO2 (0.62) | TDO2IDO1CYP3A4 | |
| SCHEMBL17651989 | 0.69 | TDO2 (1.00) | TDO2IDO1CYP11B1CYP11B2CYP3A4 | |
| SCHEMBL17651965 | 0.69 | TDO2 (0.56) | TDO2IDO1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016051181-A1 | 4H-IMIDAZO[1,5-A]INDOLE DERIVATIVES AND THEIR USE AS INDOLEAMINE 2,3-DIOXYGENASE (IDO) AND/OR TRYPTOPHAN 2,3-DIOXYGENASE (TD02) MODULATORS | REDX PHARMA PLC (GB) | 2016-04-07 | — | — | WO | disclosed |