Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDO2 | P48775 | 2/20 | 0.56 |
| ▸ | IDO1 | P14902 | 2/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.38 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.32 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.32 |
| ▸ | KDM1A | O60341 | 1/20 | 0.32 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.31 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17665690 | 0.86 | TDO2 (0.52) | TDO2IDO1CYP11B1CYP11B2CYP3A4 | |
| SCHEMBL17665688 | 0.81 | TDO2 (0.58) | TDO2IDO1CYP3A4 | |
| SCHEMBL17665342 | 0.76 | TDO2 (0.47) | TDO2IDO1 | |
| SCHEMBL17665340 | 0.76 | TDO2 (0.55) | TDO2IDO1CYP3A4 | |
| SCHEMBL17665341 | 0.74 | TDO2 (0.52) | TDO2IDO1CYP3A4 | |
| SCHEMBL17651983 | 0.73 | TDO2 (0.62) | TDO2IDO1CYP3A4 | |
| SCHEMBL17665465 | 0.73 | TDO2 (0.43) | TDO2IDO1TSHR | |
| SCHEMBL17665343 | 0.72 | TDO2 (0.45) | TDO2IDO1 | |
| SCHEMBL17665333 | 0.72 | TDO2 (0.45) | TDO2IDO1KDM1ACYP3A4 | |
| SCHEMBL17651989 | 0.71 | TDO2 (1.00) | TDO2IDO1CYP11B1CYP11B2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016051181-A1 | 4H-IMIDAZO[1,5-A]INDOLE DERIVATIVES AND THEIR USE AS INDOLEAMINE 2,3-DIOXYGENASE (IDO) AND/OR TRYPTOPHAN 2,3-DIOXYGENASE (TD02) MODULATORS | REDX PHARMA PLC (GB) | 2016-04-07 | — | — | WO | disclosed |