Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDO2 | P48775 | 3/20 | 0.49 |
| ▸ | IDO1 | P14902 | 5/20 | 0.39 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.34 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.34 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.31 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.31 |
| ▸ | CFTR | P13569 | 1/20 | 0.31 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
| ▸ | PRKCI | P41743 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17665680 | 0.88 | TDO2 (0.43) | TDO2IDO1 | |
| SCHEMBL17665353 | 0.84 | TDO2 (0.45) | TDO2IDO1HSP90AA1 | |
| SCHEMBL17651987 | 0.82 | TDO2 (0.50) | TDO2IDO1 | |
| SCHEMBL17651986 | 0.82 | TDO2 (0.43) | TDO2IDO1GPBAR1 | |
| SCHEMBL17665681 | 0.81 | TDO2 (0.43) | TDO2IDO1GPBAR1CYSLTR1 | |
| SCHEMBL17665689 | 0.80 | TDO2 (0.42) | TDO2IDO1 | |
| SCHEMBL17651997 | 0.79 | TDO2 (0.41) | TDO2IDO1CYP11B2 | |
| SCHEMBL17651977 | 0.78 | TDO2 (0.46) | TDO2IDO1SMN1; SMN2 | |
| SCHEMBL17665351 | 0.77 | TDO2 (0.48) | TDO2IDO1CYP11B2 | |
| SCHEMBL17665690 | 0.77 | TDO2 (0.52) | TDO2IDO1CYP11B1CYP11B2CFTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016051181-A1 | 4H-IMIDAZO[1,5-A]INDOLE DERIVATIVES AND THEIR USE AS INDOLEAMINE 2,3-DIOXYGENASE (IDO) AND/OR TRYPTOPHAN 2,3-DIOXYGENASE (TD02) MODULATORS | REDX PHARMA PLC (GB) | 2016-04-07 | — | — | WO | disclosed |
| WO-2016051181-A1 | 4H-IMIDAZO[1,5-A]INDOLE DERIVATIVES AND THEIR USE AS INDOLEAMINE 2,3-DIOXYGENASE (IDO) AND/OR TRYPTOPHAN 2,3-DIOXYGENASE (TD02) MODULATORS | REDX PHARMA PLC (GB) | 2016-04-07 | — | — | WO | disclosed |