Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDO2 | P48775 | 2/20 | 0.52 |
| ▸ | IDO1 | P14902 | 2/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | ATP4A | P20648 | 1/20 | 0.31 |
| ▸ | ATP4B | P51164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17665684 | 0.88 | TDO2 (0.46) | TDO2IDO1 | |
| SCHEMBL17665686 | 0.82 | TDO2 (0.47) | TDO2IDO1 | |
| SCHEMBL17651939 | 0.81 | TDO2 (0.46) | TDO2IDO1SLC6A2SLC6A4 | |
| SCHEMBL17651954 | 0.81 | TDO2 (0.46) | TDO2IDO1SLC6A2SLC6A4ATP4A | |
| SCHEMBL17651951 | 0.81 | TDO2 (0.46) | TDO2IDO1SLC6A2SLC6A4 | |
| SCHEMBL17665688 | 0.78 | TDO2 (0.58) | TDO2IDO1 | |
| SCHEMBL17651968 | 0.78 | TDO2 (0.43) | TDO2IDO1 | |
| SCHEMBL17651963 | 0.77 | TDO2 (0.49) | TDO2IDO1 | |
| SCHEMBL17651987 | 0.77 | TDO2 (0.50) | TDO2IDO1SLC6A2 | |
| SCHEMBL17665687 | 0.76 | TDO2 (0.40) | TDO2IDO1SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016051181-A1 | 4H-IMIDAZO[1,5-A]INDOLE DERIVATIVES AND THEIR USE AS INDOLEAMINE 2,3-DIOXYGENASE (IDO) AND/OR TRYPTOPHAN 2,3-DIOXYGENASE (TD02) MODULATORS | REDX PHARMA PLC (GB) | 2016-04-07 | — | — | WO | disclosed |