Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDO2 | P48775 | 1/20 | 0.47 |
| ▸ | IDO1 | P14902 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17651951 | 0.85 | TDO2 (0.46) | TDO2IDO1ALDH1A1 | |
| SCHEMBL17651954 | 0.85 | TDO2 (0.46) | TDO2IDO1 | |
| SCHEMBL17665684 | 0.84 | TDO2 (0.46) | TDO2IDO1 | |
| SCHEMBL17651968 | 0.82 | TDO2 (0.43) | TDO2IDO1 | |
| SCHEMBL17665692 | 0.82 | TDO2 (0.52) | TDO2IDO1 | |
| SCHEMBL17651987 | 0.81 | TDO2 (0.50) | TDO2IDO1 | |
| SCHEMBL17665352 | 0.81 | TDO2 (0.47) | TDO2IDO1 | |
| SCHEMBL17665351 | 0.79 | TDO2 (0.48) | TDO2IDO1 | |
| SCHEMBL17665691 | 0.79 | SLC9A3 (0.43) | TDO2ALDH1A1GPBAR1 | |
| SCHEMBL17665685 | 0.79 | TDO2 (0.41) | TDO2IDO1GPBAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016051181-A1 | 4H-IMIDAZO[1,5-A]INDOLE DERIVATIVES AND THEIR USE AS INDOLEAMINE 2,3-DIOXYGENASE (IDO) AND/OR TRYPTOPHAN 2,3-DIOXYGENASE (TD02) MODULATORS | REDX PHARMA PLC (GB) | 2016-04-07 | — | — | WO | disclosed |