Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDO2 | P48775 | 1/20 | 0.45 |
| ▸ | TNF | P01375 | 2/20 | 0.39 |
| ▸ | IDO1 | P14902 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | TOP2A | P11388 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | RAD52 | P43351 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 4/20 | 0.31 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17665685 | 0.79 | TDO2 (0.41) | TDO2TNFIDO1TOP2AMAPT | |
| SCHEMBL17665341 | 0.76 | TDO2 (0.52) | TDO2IDO1KDM4EHTTCYP3A4 | |
| SCHEMBL17665340 | 0.75 | TDO2 (0.55) | TDO2IDO1KDM4EPOLBCYP1A2 | |
| SCHEMBL17665679 | 0.72 | TDO2 (0.41) | TDO2IDO1KDM4EHTTLMNA | |
| SCHEMBL17665688 | 0.71 | TDO2 (0.58) | TDO2IDO1CYP3A4 | |
| SCHEMBL17651965 | 0.70 | TDO2 (0.56) | TDO2IDO1CYP3A4 | |
| SCHEMBL17651983 | 0.69 | TDO2 (0.62) | TDO2IDO1CYP3A4 | |
| SCHEMBL17665342 | 0.68 | TDO2 (0.47) | TDO2IDO1 | |
| SCHEMBL18157867 | 0.67 | TDO2 (0.56) | TDO2IDO1CYP3A4 | |
| SCHEMBL17665348 | 0.67 | IKBKB (0.45) | TDO2IDO1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016051181-A1 | 4H-IMIDAZO[1,5-A]INDOLE DERIVATIVES AND THEIR USE AS INDOLEAMINE 2,3-DIOXYGENASE (IDO) AND/OR TRYPTOPHAN 2,3-DIOXYGENASE (TD02) MODULATORS | REDX PHARMA PLC (GB) | 2016-04-07 | — | — | WO | disclosed |