Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDO2 | P48775 | 1/20 | 0.52 |
| ▸ | IDO1 | P14902 | 3/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17665340 | 0.83 | TDO2 (0.55) | TDO2IDO1ACHEKDM4EGAA | |
| SCHEMBL17665688 | 0.79 | TDO2 (0.58) | TDO2IDO1ACHECYP3A4 | |
| SCHEMBL17651965 | 0.78 | TDO2 (0.56) | TDO2IDO1ACHECYP3A4HCAR1 | |
| SCHEMBL17665686 | 0.78 | TDO2 (0.47) | TDO2IDO1 | |
| SCHEMBL17665483 | 0.77 | TDO2 (0.46) | TDO2IDO1KDM4EGAA | |
| SCHEMBL17651983 | 0.76 | TDO2 (0.62) | TDO2IDO1ACHECYP3A4HCAR1 | |
| SCHEMBL17665693 | 0.76 | TDO2 (0.45) | TDO2IDO1KDM4ECYP3A4HTT | |
| SCHEMBL18157867 | 0.75 | TDO2 (0.56) | TDO2IDO1ACHECYP3A4HCAR1 | |
| SCHEMBL17665682 | 0.74 | TDO2 (0.56) | TDO2IDO1CYP3A4 | |
| SCHEMBL17651987 | 0.72 | TDO2 (0.50) | TDO2IDO1GAACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016051181-A1 | 4H-IMIDAZO[1,5-A]INDOLE DERIVATIVES AND THEIR USE AS INDOLEAMINE 2,3-DIOXYGENASE (IDO) AND/OR TRYPTOPHAN 2,3-DIOXYGENASE (TD02) MODULATORS | REDX PHARMA PLC (GB) | 2016-04-07 | — | — | WO | disclosed |