Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDO2 | P48775 | 1/20 | 0.47 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.33 |
| ▸ | PNMT | P11086 | 1/20 | 0.31 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.31 |
| ▸ | F10 | P00742 | 1/20 | 0.31 |
| ▸ | PLG | P00747 | 1/20 | 0.31 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.31 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.30 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.30 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17665690 | 0.89 | TDO2 (0.52) | TDO2IDO1PRSS1ABCB1 | |
| SCHEMBL17665465 | 0.85 | TDO2 (0.43) | TDO2IDO1ABCB1 | |
| SCHEMBL17665680 | 0.78 | TDO2 (0.43) | TDO2IDO1LOXL2 | |
| SCHEMBL17665333 | 0.78 | TDO2 (0.45) | TDO2IDO1 | |
| SCHEMBL17665343 | 0.78 | TDO2 (0.45) | TDO2IDO1 | |
| SCHEMBL17665682 | 0.76 | TDO2 (0.56) | TDO2IDO1 | |
| SCHEMBL17665341 | 0.72 | TDO2 (0.52) | TDO2IDO1 | |
| SCHEMBL17665340 | 0.71 | TDO2 (0.55) | TDO2IDO1 | |
| SCHEMBL17665688 | 0.70 | TDO2 (0.58) | TDO2IDO1 | |
| SCHEMBL17651993 | 0.70 | TDO2 (0.74) | TDO2IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016051181-A1 | 4H-IMIDAZO[1,5-A]INDOLE DERIVATIVES AND THEIR USE AS INDOLEAMINE 2,3-DIOXYGENASE (IDO) AND/OR TRYPTOPHAN 2,3-DIOXYGENASE (TD02) MODULATORS | REDX PHARMA PLC (GB) | 2016-04-07 | — | — | WO | disclosed |