SCHEMBL17667126

SCHEMBL17667126

CC1(C)c2ccc(Br)cc2-c2c1c1ccccc1n2-c1ccccc1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ PDE4B Q07343 1/20 0.42
▸ L3MBTL1 Q9Y468 3/20 0.40
▸ KDM4E B2RXH2 1/20 0.40
▸ ATM Q13315 1/20 0.40
▸ IL1R1 P14778 1/20 0.38
▸ MAPT P10636 5/20 0.37
▸ KMT2A Q03164 3/20 0.37
▸ MEN1 O00255 2/20 0.37
▸ HTT P42858 2/20 0.37
▸ ALDH1A1 P00352 2/20 0.37
▸ RAB9A P51151 1/20 0.35
▸ IDO1 P14902 1/20 0.34
▸ TDO2 P48775 1/20 0.34
▸ IDO2 Q6ZQW0 1/20 0.34
▸ MDM2 Q00987 1/20 0.33
▸ RXFP1 Q9HBX9 2/20 0.33
▸ MAPK8 P45983 1/20 0.33
▸ GAA P10253 2/20 0.32
▸ MGAM O43451 1/20 0.32
▸ SI P14410 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17667131 0.94 PDE4B (0.40) PDE4BL3MBTL1KDM4EATMIL1R1
SCHEMBL17667139 0.91 PDE4B (0.37) PDE4BL3MBTL1KDM4EATMIL1R1
SCHEMBL17667102 0.88 L3MBTL1 (0.43) L3MBTL1KDM4EATMIL1R1MAPT
SCHEMBL17667111 0.86 PDE4B (0.33) PDE4BMAPTKMT2AMEN1HTT
SCHEMBL17667116 0.85 L3MBTL1 (0.46) L3MBTL1KDM4EATMIL1R1MAPT
SCHEMBL17667135 0.83 L3MBTL1 (0.46) L3MBTL1KDM4EATMIL1R1MAPT
SCHEMBL25742242 0.82 L3MBTL1 (0.39) PDE4BL3MBTL1KDM4EATMMAPT
SCHEMBL18201371 0.80 L3MBTL1 (0.43) PDE4BL3MBTL1KDM4EATMIL1R1
SCHEMBL15894370 0.80 IL1R1 (0.38) L3MBTL1KDM4EATMIL1R1MAPT
SCHEMBL17996090 0.80 L3MBTL1 (0.45) PDE4BL3MBTL1KDM4EATMMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3006426-B1 INDENOINDOLE DERIVATIVE AND ORGANIC ELECTROLUMINESCENT ELEMENT HODOGAYA CHEMICAL CO LTD (JP) 2019-01-09 — — EP disclosed
US-9985216-B2 Indenoindole derivative and organic electroluminescent element HODOGAYA CHEMICAL CO., LTD. (JP) 2018-05-29 — — US disclosed
US-20160126468-A1 INDENOINDOLE DERIVATIVE AND ORGANIC ELECTROLUMINESCENT ELEMENT HODOGAYA CHEMICAL CO., LTD. (JP) 2016-05-05 — — US disclosed
EP-3006426-A1 INDENOINDOLE DERIVATIVE AND ORGANIC ELECTROLUMINESCENT ELEMENT Hodogaya Chemical Co., Ltd. (JP) 2016-04-13 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160126468-A1 INDENOINDOLE DERIVATIVE AND ORGANIC ELECTROLUMINESCENT ELEMENT IDO2, SLCO2B1, IDO1 PDE4B 4126/4885L3MBTL1 2737/4885KDM4E 922/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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