Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.44 |
| ▸ | LMNA | P02545 | 5/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.44 |
| ▸ | HTT | P42858 | 3/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | NR3C1 | P04150 | 14/20 | 0.39 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.39 |
| ▸ | AR | P10275 | 2/20 | 0.39 |
| ▸ | PGR | P06401 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1314927 | 0.91 | MAPT (0.42) | MAPTLMNANPSR1HTTTP53 | |
| SCHEMBL1780352 | 0.88 | MAPT (0.41) | MAPTLMNANPSR1HTTTP53 | |
| SCHEMBL1780365 | 0.88 | MAPT (0.41) | MAPTLMNANPSR1HTTTP53 | |
| SCHEMBL1316150 | 0.87 | MAPT (0.49) | MAPTLMNANPSR1HTTTP53 | |
| SCHEMBL1314233 | 0.86 | LMNA (0.62) | MAPTLMNANPSR1HTTTP53 | |
| SCHEMBL1314508 | 0.85 | LMNA (0.42) | MAPTLMNANPSR1HTTTP53 | |
| SCHEMBL1829316 | 0.84 | MAPT (0.44) | MAPTLMNANPSR1HTTTP53 | |
| SCHEMBL1314852 | 0.84 | MAPT (0.41) | MAPTLMNANPSR1HTTTP53 | |
| SCHEMBL17667957 | 0.84 | MAPT (0.45) | MAPTLMNANPSR1HTTTP53 | |
| SCHEMBL1315415 | 0.83 | NR3C1 (0.42) | MAPTLMNANPSR1HTTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2319835-B1 | GLUCOCORTICOID RECEPTOR AGONIST COMPOSED OF 2,2,4-TRIMETHYL-6-PHENYL-1,2-DIHYDROQUINOLINE DERIVATIVE HAVING SUBSTITUTED OXY GROUP | AYUMI PHARMACEUTICAL CORP (JP) | 2016-04-13 | — | — | EP | claimed |