Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 4/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | THRB | P10828 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | CCR2 | P41597 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17674247 | 0.81 | NTRK1 (0.47) | NTRK1RXFP1LMNATHRBTP53 | |
| SCHEMBL17680316 | 0.78 | NTRK1 (0.44) | NTRK1RXFP1LMNATHRBTP53 | |
| SCHEMBL17680320 | 0.77 | NTRK1 (0.47) | NTRK1RXFP1LMNATHRBTP53 | |
| SCHEMBL17680425 | 0.77 | NTRK1 (0.48) | NTRK1RXFP1LMNATHRBTP53 | |
| SCHEMBL17674435 | 0.76 | NTRK1 (0.57) | NTRK1RXFP1LMNATP53MAPT | |
| SCHEMBL17674391 | 0.76 | NTRK1 (0.60) | NTRK1RXFP1LMNATHRBL3MBTL1 | |
| SCHEMBL17680501 | 0.76 | L3MBTL1 (0.71) | NTRK1RXFP1LMNATHRBL3MBTL1 | |
| SCHEMBL17674385 | 0.75 | NTRK1 (0.45) | NTRK1RXFP1LMNATHRBTP53 | |
| SCHEMBL17680515 | 0.75 | NTRK1 (0.45) | NTRK1RXFP1LMNATHRBTP53 | |
| SCHEMBL17674310 | 0.74 | NTRK1 (0.54) | NTRK1RXFP1LMNATHRBTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016054807-A1 | TrkA KINASE INHIBITORS, COMPOSITIONS AND METHODS THEREOF | MERCK SHARP & DOHME CORP. (US) | 2016-04-14 | — | — | WO | disclosed |
| WO-2016054807-A1 | TrkA KINASE INHIBITORS, COMPOSITIONS AND METHODS THEREOF | MERCK SHARP & DOHME CORP. (US) | 2016-04-14 | — | — | WO | disclosed |