Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | THRB | P10828 | 2/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 3/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CCR2 | P41597 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17674262 | 0.77 | NTRK1 (0.50) | NTRK1LMNATHRBRXFP1TP53 | |
| SCHEMBL17680501 | 0.77 | L3MBTL1 (0.71) | NTRK1LMNATHRBRXFP1L3MBTL1 | |
| SCHEMBL17680316 | 0.76 | NTRK1 (0.44) | NTRK1LMNATHRBRXFP1TP53 | |
| SCHEMBL17680425 | 0.76 | NTRK1 (0.48) | NTRK1LMNATHRBRXFP1TP53 | |
| SCHEMBL17674247 | 0.75 | NTRK1 (0.47) | NTRK1LMNATHRBRXFP1TP53 | |
| SCHEMBL17674385 | 0.73 | NTRK1 (0.45) | NTRK1LMNATHRBRXFP1TP53 | |
| SCHEMBL17680515 | 0.73 | NTRK1 (0.45) | NTRK1LMNATHRBRXFP1TP53 | |
| SCHEMBL17674270 | 0.73 | NTRK1 (0.53) | NTRK1LMNATHRBRXFP1TP53 | |
| SCHEMBL17674419 | 0.72 | NTRK1 (0.44) | NTRK1LMNATHRBRXFP1L3MBTL1 | |
| SCHEMBL17674391 | 0.72 | NTRK1 (0.60) | NTRK1LMNATHRBRXFP1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016054807-A1 | TrkA KINASE INHIBITORS, COMPOSITIONS AND METHODS THEREOF | MERCK SHARP & DOHME CORP. (US) | 2016-04-14 | — | — | WO | disclosed |