Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | GPR55 | Q9Y2T6 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | HPN | P05981 | 1/20 | 0.38 |
| ▸ | XBP1 | P17861 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.37 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.37 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2868955 | 0.86 | ALDH1A1 (0.39) | AAK1MAPTNPSR1TDP1KDM4E | |
| SCHEMBL17493990 | 0.78 | AAK1 (0.49) | AAK1BCHE | |
| SCHEMBL7447720 | 0.77 | GRM2 (0.49) | MAPTNPSR1TDP1L3MBTL1GRM2 | |
| SCHEMBL17515956 | 0.77 | AAK1 (0.44) | AAK1MAPTNPSR1POLBBCHE | |
| SCHEMBL2866759 | 0.77 | ALDH1A1 (0.39) | AAK1MAPTNPSR1TDP1POLB | |
| SCHEMBL17516167 | 0.76 | AAK1 (0.46) | AAK1MAPTNPSR1POLBBCHE | |
| Hydrochloric Acid SCHEMBL17416399 | 0.76 | KMT2A (0.33) | AAK1MAPTKDM4E | |
| SCHEMBL17494035 | 0.76 | AAK1 (0.63) | AAK1BCHE | |
| SCHEMBL12798924 | 0.73 | AAK1 (0.48) | AAK1MAPTL3MBTL1BCHE | |
| SCHEMBL7921079 | 0.72 | AAK1 (0.47) | AAK1MAPTL3MBTL1BCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3204375-A1 | SPIRO-INDOLINES FOR THE TREATMENT AND PROPHYLAXIS OF RESPIRATORY SYNCYTIAL VIRUS INFECTION (RSV) | Reviral Limited (GB) | 2017-08-16 | — | — | EP | disclosed |
| WO-2016055780-A1 | SPIRO-INDOLINES FOR THE TREATMENT AND PROPHYLAXIS OF RESPIRATORY SYNCYTIAL VIRUS INFECTION (RSV) | RE:VIRAL LTD (GB) | 2016-04-14 | — | — | WO | disclosed |