Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | BCHE | P06276 | 1/20 | 0.46 |
| ▸ | HPN | P05981 | 1/20 | 0.46 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.43 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.43 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.43 |
| ▸ | KDM4A | O75164 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14431418 | 0.88 | BCHE (0.49) | GRM2BCHEHPNNAMPTMAPT | |
| SCHEMBL22775707 | 0.79 | CACNA1H (0.53) | GRM2L3MBTL1BCHEHPNCACNA1H | |
| SCHEMBL29613729 | 0.79 | CACNA1H (0.53) | GRM2L3MBTL1BCHEHPNCACNA1H | |
| SCHEMBL17675682 | 0.77 | AAK1 (0.44) | GRM2L3MBTL1BCHEHPNCACNA1H | |
| SCHEMBL16729280 | 0.77 | ALDH1A1 (0.67) | MAPT | |
| SCHEMBL29377817 | 0.77 | ALDH1A1 (0.67) | MAPT | |
| SCHEMBL24376424 | 0.76 | GRM2 (0.52) | GRM2L3MBTL1KDM4ANAMPTCYP1A2 | |
| SCHEMBL22511718 | 0.76 | GRM2 (0.57) | GRM2L3MBTL1KDM4ANAMPTDYRK1A | |
| SCHEMBL1616470 | 0.76 | HPN (0.52) | GRM2L3MBTL1HPNMAPT | |
| SCHEMBL10209975 | 0.76 | L3MBTL1 (0.47) | L3MBTL1HPNKDM4ANAMPTMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002014349-A2 | NON-COVALENT INHIBITORS OF UROKINASE AND BLOOD VESSEL FORMATION | CORVAS INTERNATIONAL, INC. (US) | 2002-02-21 | — | — | WO | disclosed |