Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16473874 | 0.98 | ALDH1A1 (0.36) | ALDH1A1TSHRTHRBHSD17B10 | |
| SCHEMBL16473877 | 0.93 | THRB (0.35) | TSHRTHRBHSD17B10 | |
| SCHEMBL12240798 | 0.90 | THRB (0.36) | TSHRTHRBHSD17B10 | |
| SCHEMBL14616902 | 0.87 | HSD17B10 (0.33) | ALDH1A1THRBHSD17B10 | |
| SCHEMBL14616850 | 0.87 | HSD17B10 (0.33) | ALDH1A1THRBHSD17B10 | |
| SCHEMBL14616849 | 0.87 | HSD17B10 (0.33) | ALDH1A1THRBHSD17B10 | |
| SCHEMBL10051721 | 0.84 | HSD17B10 (0.38) | THRBHSD17B10 | |
| SCHEMBL20089590 | 0.83 | THRB (0.38) | TSHRTHRBHSD17B10 | |
| SCHEMBL11970056 | 0.82 | ALDH1A1 (0.47) | ALDH1A1TSHRTHRBHSD17B10 | |
| SCHEMBL394975 | 0.82 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9878047-B2 | Prodrugs of peptide epoxy ketone protease inhibitors | ONYX THERAPEUTICS, INC. (US) | 2018-01-30 | — | — | US | disclosed |
| US-20160263234-A1 | PRODRUGS OF PEPTIDE EPOXY KETONE PROTEASE INHIBITORS | ONYX THERAPEUTICS, INC. | 2016-09-15 | — | — | US | disclosed |
| US-9309283-B2 | Prodrugs of peptide epoxy ketone protease inhibitors | ONYX THERAPEUTICS, INC. (US) | 2016-04-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160263234-A1 | PRODRUGS OF PEPTIDE EPOXY KETONE PROTEASE INHIBITORS | PREP, VIP, PEPD | ALDH1A1 1285/4885TSHR 3808/4885THRB 2120/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.