Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.46 |
| ▸ | ASPH | Q12797 | 1/20 | 0.46 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.44 |
| ▸ | KDM4A | O75164 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.44 |
| ▸ | HIF1AN | Q9NWT6 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | MYC | P01106 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | AGER | Q15109 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14335806 | 0.81 | KDM4E (0.52) | KDM4EASPHKDM8TDP1L3MBTL1 | |
| SCHEMBL353106 | 0.81 | KDM4E (0.47) | KDM4EASPHKDM8TDP1L3MBTL1 | |
| SCHEMBL16094649 | 0.80 | KDM4E (0.52) | KDM4EASPHKDM8TDP1L3MBTL1 | |
| SCHEMBL19857487 | 0.79 | KDM4E (0.60) | KDM4EASPHKDM8TDP1L3MBTL1 | |
| SCHEMBL245080 | 0.78 | KDM4E (0.48) | KDM4EASPHKDM8TDP1L3MBTL1 | |
| SCHEMBL480040 | 0.78 | NAPRT (0.55) | KDM4EASPHKDM8TDP1L3MBTL1 | |
| SCHEMBL112760 | 0.78 | KDM4E (0.44) | KDM4EASPHKDM8TDP1L3MBTL1 | |
| SCHEMBL581067 | 0.78 | SMN1; SMN2 (0.55) | KDM4EASPHKDM8TDP1L3MBTL1 | |
| SCHEMBL2027279 | 0.78 | NAPRT (0.55) | KDM4EASPHKDM8TDP1L3MBTL1 | |
| SCHEMBL27843532 | 0.78 | KDM4E (0.44) | KDM4EASPHKDM8TDP1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2694480-B1 | ADAMANTYL COMPOUNDS | HOFFMANN LA ROCHE (CH) | 2015-03-04 | — | — | EP | disclosed |
| EP-2694480-A1 | ADAMANTYL COMPOUNDS | F.HOFFMANN-LA ROCHE AG (CH) | 2014-02-12 | — | — | EP | disclosed |
| US-8471027-B2 | Adamantyl compounds | HOFFMANN-LA ROCHE INC. (US) | 2013-06-25 | — | — | US | disclosed |
| WO-2012136684-A1 | ADAMANTYL COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2012-10-11 | — | — | WO | disclosed |
| US-20120258982-A1 | ADAMANTYL COMPOUNDS | CHEUNG ADRIAN WAI-HING (US) | 2012-10-11 | — | — | US | disclosed |
| US-20110112114-A1 | INHIBITORS OF SERINE PROTEASES, PARTICULARLY HEPATITIS C VIRUS NS3 PROTEASE | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-05-12 | — | — | US | disclosed |
| EP-1066247-B1 | INHIBITORS OF SERINE PROTEASES, PARTICULARLY HEPATITIS C VIRUS NS3 PROTEASE | VERTEX PHARMA (US) | 2006-11-22 | — | — | EP | disclosed |
| US-20040077600-A1 | Inhibitors of serine proteases, particularly hepatitis C virus NS3 protease | TUNG ROGER D (US) | 2004-04-22 | — | — | US | disclosed |
| US-6608067-B1 | Treating hepatitis C viral infection | VERTEX PHARMACEUTICALS INCORPORATED | 2003-08-19 | — | — | US | disclosed |
| US-20020065264-A1 | Cysteine protease inhibitors containing heterocyclic leaving groups | ZIMMERMAN MARY P (US) | 2002-05-30 | — | — | US | disclosed |
| US-6297277-B1 | PEPTIDYL KETONES HAVING HETEROCYCLIC LEAVING GROUPS; CATHEPSIN INHIBITORS | PROTOTEK, INC. | 2001-10-02 | — | — | US | disclosed |
| EP-1066247-A1 | INHIBITORS OF SERINE PROTEASES, PARTICULARLY HEPATITIS C VIRUS NS3 PROTEASE | Vertex Pharmaceuticals Incorporated (US) | 2001-01-10 | — | — | EP | disclosed |
| WO-2000066522-A1 | GLUCOCORTICOID RECEPTOR MODULATORS | PFIZER PRODUCTS INC. (US) | 2000-11-09 | — | — | WO | disclosed |
| WO-1999050230-A1 | INHIBITORS OF SERINE PROTEASES, PARTICULARLY HEPATITIS C VIRUS NS3 PROTEASE | VERTEX PHARMACEUTICALS INCORPORATED (US) | 1999-10-07 | — | — | WO | disclosed |
| US-5925772-A | ENZYME INHIBITORS FOR ANTIARTHRITIC AGENTS FROM HETEROCYCLIC PEPTIDES | PROTOTEK, INC. (US) | 1999-07-20 | — | — | US | disclosed |
| EP-0731696-A4 | CYSTEINE PROTEASE INHIBITORS CONTAINING HETEROCYCLIC LEAVING GROUPS | PROTOTEK INC (US) | 1999-04-21 | — | — | EP | disclosed |
| US-5663380-A | ANTIARTHRITIC AGENTS; TREATMENT OF RHEUMATOID ARTHRITIS | PROTOTEK, INC. (US) | 1997-09-02 | — | — | US | disclosed |
| EP-0731696-A1 | CYSTEINE PROTEASE INHIBITORS CONTAINING HETEROCYCLIC LEAVING GROUPS | PROTOTEK, INC. (US) | 1996-09-18 | — | — | EP | disclosed |
| US-5486623-A | Cysteine protease inhibitors containing heterocyclic leaving groups | PROTOTEK, INC. (US) | 1996-01-23 | — | — | US | disclosed |
| WO-1995015749-A1 | CYSTEINE PROTEASE INHIBITORS CONTAINING HETEROCYCLIC LEAVING GROUPS | PROTOTEK, INC. (US) | 1995-06-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020065264-A1 | Cysteine protease inhibitors containing heterocyclic leaving groups | HPN, PREP, SPINT2 | KDM4E 3850/4885ASPH 316/4885KDM8 334/4885 |
| US-20120258982-A1 | ADAMANTYL COMPOUNDS | MAP3K1, MAP3K6, MAPKAPK2 | KDM4E 3535/4885ASPH 645/4885KDM8 2051/4885 |
| US-20040077600-A1 | Inhibitors of serine proteases, particularly hepatitis C virus NS3 protease | HPN, PRSS1, PRSS3 | KDM4E 3387/4885ASPH 588/4885KDM8 824/4885 |
| US-20110112114-A1 | INHIBITORS OF SERINE PROTEASES, PARTICULARLY HEPATITIS C VIRUS NS3 PROTEASE | HPN, PRSS1, PRSS3 | KDM4E 3387/4885ASPH 588/4885KDM8 824/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.