Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 20/20 | 0.82 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1767937 | 1.00 | TLR8 (0.82) | TLR8 | |
| SCHEMBL16836327 | 0.92 | TLR8 (0.97) | TLR8 | |
| SCHEMBL16486514 | 0.90 | TLR8 (1.00) | TLR8 | |
| SCHEMBL16836409 | 0.86 | TLR8 (1.00) | TLR8 | |
| SCHEMBL19890256 | 0.83 | TLR8 (0.58) | TLR8 | |
| SCHEMBL19890243 | 0.78 | TLR8 (0.52) | TLR8 | |
| SCHEMBL27524791 | 0.77 | TLR8 (0.70) | TLR8 | |
| SCHEMBL1767933 | 0.77 | FAAH (0.56) | TLR8 | |
| SCHEMBL11140678 | 0.76 | TLR8 (0.47) | TLR8 | |
| SCHEMBL16848237 | 0.76 | TLR8 (1.00) | TLR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2504330-A1 | AMINO HETEROARYL COMPOUNDS AS BETA-SECRETASE MODULATORS AND METHODS OF USE | Amgen Inc. (US) | 2012-10-03 | — | — | EP | disclosed |
| WO-2011063272-A1 | AMINO HETEROARYL COMPOUNDS AS BETA-SECRETASE MODULATORS AND METHODS OF USE | AMGEN INC. (US) | 2011-05-26 | — | — | WO | disclosed |