Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2 | P11137 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MITF | O75030 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
| ▸ | GPR3 | P46089 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18824256 | 0.77 | MAP2 (0.62) | MAP2KDM4ETDP1ALDH1A1ATM | |
| SCHEMBL3203918 | 0.77 | KDM4E (0.49) | MAP2KDM4ETDP1ALDH1A1ATM | |
| SCHEMBL10596909 | 0.77 | KDM4E (0.49) | MAP2KDM4ETDP1ALDH1A1ATM | |
| SCHEMBL3788709 | 0.75 | GABRA1 (0.49) | KDM4ETDP1ALDH1A1NR4A2KMT2A | |
| SCHEMBL29050101 | 0.75 | MEN1 (0.61) | MAP2KDM4ETDP1ALDH1A1KMT2A | |
| SCHEMBL3624515 | 0.75 | NR4A2 (0.65) | KDM4EALDH1A1NR4A2KMT2AMITF | |
| SCHEMBL29025503 | 0.75 | MAP2 (0.47) | MAP2KDM4ETDP1ALDH1A1ATM | |
| SCHEMBL721793 | 0.74 | MAP2 (0.58) | MAP2KDM4ETDP1ALDH1A1KMT2A | |
| SCHEMBL6857314 | 0.72 | MAP2 (0.45) | MAP2KDM4ETDP1ALDH1A1ATM | |
| SCHEMBL4120335 | 0.71 | ALDH1A1 (0.57) | KDM4ETDP1ALDH1A1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9403803-B2 | Indole-3-carboxamides as kinase inhibitors | ALLERGAN, INC. (US) | 2016-08-02 | — | — | US | disclosed |
| US-9403803-B2 | Indole-3-carboxamides as kinase inhibitors | ALLERGAN, INC. (US) | 2016-08-02 | — | — | US | disclosed |
| US-20160102077-A1 | Indole-3-Carboxamides as Kinase Inhibitors | ALLERGAN, INC. | 2016-04-14 | — | — | US | disclosed |
| US-20160102077-A1 | Indole-3-Carboxamides as Kinase Inhibitors | ALLERGAN, INC. | 2016-04-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160102077-A1 | Indole-3-Carboxamides as Kinase Inhibitors | JAK2, REN, IGF1R | MAP2 619/4885KDM4E 460/4885TDP1 3680/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.