Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PYCR1 | P32322 | 1/20 | 0.47 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.41 |
| ▸ | AKR1B1 | P15121 | 4/20 | 0.41 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.41 |
| ▸ | NAAA | Q02083 | 1/20 | 0.40 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | TRAP1 | Q12931 | 3/20 | 0.38 |
| ▸ | HSP90B1 | P14625 | 2/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.38 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29609415 | 0.82 | CSNK2A1 (0.49) | PYCR1DGAT1AKR1B1PDPK1NAAA | |
| SCHEMBL5825 | 0.82 | CSNK2A1 (0.49) | PYCR1DGAT1AKR1B1PDPK1NAAA | |
| SCHEMBL4798349 | 0.81 | PYCR1 (0.43) | PYCR1DGAT1KDM1AHSP90AA1 | |
| SCHEMBL6140760 | 0.78 | IDO1 (0.50) | — | |
| SCHEMBL1310479 | 0.78 | PYCR1 (0.50) | PYCR1DGAT1AKR1B1PDPK1NAAA | |
| SCHEMBL2094594 | 0.78 | PYCR1 (0.46) | PYCR1DGAT1AKR1B1PDPK1NAAA | |
| SCHEMBL7750833 | 0.77 | PYCR1 (0.46) | PYCR1DGAT1AKR1B1PDPK1NAAA | |
| SCHEMBL5546199 | 0.77 | KDM1A (0.44) | PYCR1AKR1B1CHRM5KDM1ATRAP1 | |
| SCHEMBL2097280 | 0.77 | NAAA (0.49) | PYCR1DGAT1AKR1B1PDPK1NAAA | |
| SCHEMBL1758502 | 0.77 | HSP90AA1 (0.41) | PYCR1DGAT1HSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2504338-B1 | PYRIDINE-PYRIDINONE DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI SA (FR) | 2015-03-18 | — | — | EP | disclosed |
| EP-2504338-A1 | PYRIDINE-PYRIDINONE DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2012-10-03 | — | — | EP | disclosed |
| WO-2011061458-A1 | PYRIDINE-PYRIDINONE DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2011-05-26 | — | — | WO | disclosed |