Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PYCR1 | P32322 | 1/20 | 0.46 |
| ▸ | NAAA | Q02083 | 1/20 | 0.40 |
| ▸ | TRAP1 | Q12931 | 5/20 | 0.38 |
| ▸ | HSP90B1 | P14625 | 3/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.38 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.38 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.38 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.37 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.36 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2106707 | 0.82 | NAAA (0.49) | PYCR1NAAATRAP1HSP90B1HSP90AA1 | |
| SCHEMBL1647830 | 0.81 | IDO1 (0.44) | P2RX7 | |
| SCHEMBL29226224 | 0.79 | BACE1 (0.38) | PYCR1 | |
| SCHEMBL1768047 | 0.77 | PYCR1 (0.47) | PYCR1NAAATRAP1HSP90B1HSP90AA1 | |
| SCHEMBL6773244 | 0.76 | PYCR1 (0.38) | PYCR1 | |
| SCHEMBL28636567 | 0.76 | GABRA1 (0.33) | — | |
| SCHEMBL1649587 | 0.75 | DPP4 (0.34) | — | |
| SCHEMBL6049 | 0.73 | TAAR1 (0.43) | — | |
| SCHEMBL2094594 | 0.72 | PYCR1 (0.46) | PYCR1NAAATRAP1HSP90B1HSP90AA1 | |
| SCHEMBL1310479 | 0.72 | PYCR1 (0.50) | PYCR1NAAATRAP1HSP90B1AKR1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0712849-B1 | Process of preparation of substituted quinazolin-2,4-diones | CLARIANT GMBH (DE) | 2001-01-17 | — | — | EP | claimed |
| US-5710319-A | Process for the preparation of substituted quinazoline-2,4-diones | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-01-20 | — | — | US | claimed |
| EP-0712849-A2 | Process of preparation of substituted quinazolin-2,4-diones | HOECHST AKTIENGESELLSCHAFT (DE) | 1996-05-22 | — | — | EP | claimed |
| JP-8253458-A | — | — | None | — | — | JP | disclosed |
| EP-0712849-B1 | Process of preparation of substituted quinazolin-2,4-diones | CLARIANT GMBH (DE) | 2001-01-17 | — | — | EP | disclosed |
| US-5710319-A | Process for the preparation of substituted quinazoline-2,4-diones | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-01-20 | — | — | US | disclosed |
| JP-H08253458-A | PRODUCTION OF SUBSTITUTED QUINAZOLINE-2,4-DIONE | HOECHST AG | 1996-10-01 | — | — | JP | disclosed |
| EP-0712849-A2 | Process of preparation of substituted quinazolin-2,4-diones | HOECHST AKTIENGESELLSCHAFT (DE) | 1996-05-22 | — | — | EP | disclosed |