Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.38 |
| ▸ | TTR | P02766 | 3/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.37 |
| ▸ | TXNRD3 | Q86VQ6 | 1/20 | 0.37 |
| ▸ | TXNRD2 | Q9NNW7 | 1/20 | 0.37 |
| ▸ | HSPB1 | P04792 | 3/20 | 0.37 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.36 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.36 |
| ▸ | EPAS1 | Q99814 | 2/20 | 0.34 |
| ▸ | TYMS | P04818 | 1/20 | 0.34 |
| ▸ | ESPL1 | Q14674 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12066584 | 0.84 | TDP1 (0.52) | TDP1ATMALDH1A1HIF1ATTR | |
| SCHEMBL13113132 | 0.82 | TTR (0.51) | TDP1ATMALDH1A1HIF1ATTR | |
| SCHEMBL1999340 | 0.78 | TDP1 (0.57) | TDP1ATMALDH1A1HIF1ATTR | |
| SCHEMBL29966805 | 0.78 | TDP1 (0.57) | TDP1ATMALDH1A1HIF1ATTR | |
| SCHEMBL13113133 | 0.77 | TPMT (0.44) | TDP1ATMALDH1A1TTRCYP3A4 | |
| SCHEMBL25355019 | 0.75 | TTR (0.49) | TDP1ATMALDH1A1HIF1ATTR | |
| SCHEMBL8091607 | 0.75 | TDP1 (0.44) | TDP1ATMALDH1A1HIF1ATTR | |
| SCHEMBL30949511 | 0.75 | TDP1 (0.44) | TDP1ATMALDH1A1HIF1ATTR | |
| SCHEMBL9847876 | 0.75 | TSHR (0.44) | TDP1ATMALDH1A1HIF1ACYP3A4 | |
| SCHEMBL2132590 | 0.75 | TDP1 (0.44) | TDP1ATMALDH1A1HIF1ATTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016055028-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2016-04-14 | — | — | WO | disclosed |