Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.77 |
| ▸ | MEN1 | O00255 | 4/20 | 0.77 |
| ▸ | POLB | P06746 | 2/20 | 0.77 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.69 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.57 |
| ▸ | GAA | P10253 | 3/20 | 0.55 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11578349 | 0.86 | HPGD (0.65) | KMT2AMEN1POLBALDH1A1KDM4E | |
| SCHEMBL9620133 | 0.84 | GAA (0.77) | KMT2AMEN1POLBALDH1A1KDM4E | |
| SCHEMBL8773849 | 0.84 | MEN1 (0.67) | KMT2AMEN1POLBALDH1A1KDM4E | |
| SCHEMBL54924 | 0.84 | MEN1 (0.80) | KMT2AMEN1POLBALDH1A1CYP3A4 | |
| SCHEMBL30116158 | 0.84 | ALDH1A1 (0.56) | KMT2AMEN1POLBALDH1A1KDM4E | |
| SCHEMBL20597334 | 0.84 | ALDH1A1 (0.56) | KMT2AMEN1POLBALDH1A1KDM4E | |
| SCHEMBL12900894 | 0.84 | ALDH1A1 (0.56) | KMT2AMEN1POLBALDH1A1KDM4E | |
| SCHEMBL2680891 | 0.84 | MEN1 (0.79) | KMT2AMEN1POLBALDH1A1CYP3A4 | |
| SCHEMBL21765858 | 0.83 | CYP3A4 (0.56) | KMT2AMEN1POLBALDH1A1KDM4E | |
| SCHEMBL7934469 | 0.82 | POLB (0.77) | KMT2AMEN1POLBALDH1A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016055028-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2016-04-14 | — | — | WO | disclosed |