Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TPH1 | P17752 | 18/20 | 0.55 |
| ▸ | SLC7A11 | Q9UPY5 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2237775 | 0.87 | TPH1 (0.70) | TPH1 | |
| SCHEMBL1129389 | 0.87 | TPH1 (0.70) | TPH1 | |
| SCHEMBL871148 | 0.84 | TPH1 (0.77) | TPH1 | |
| SCHEMBL27726662 | 0.84 | TPH1 (0.77) | TPH1 | |
| SCHEMBL871149 | 0.84 | TPH1 (0.77) | TPH1 | |
| SCHEMBL1768161 | 0.79 | TPH1 (0.62) | TPH1 | |
| SCHEMBL1768157 | 0.75 | TPH1 (0.49) | TPH1 | |
| SCHEMBL1873079 | 0.74 | TPH1 (0.83) | TPH1 | |
| SCHEMBL1129126 | 0.73 | TPH1 (0.55) | TPH1 | |
| SCHEMBL1880944 | 0.73 | TPH1 (0.55) | TPH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014082034-A1 | METHODS FOR TREATING IRRITABLE BOWEL SYNDROME | LEXICON PHARMACEUTICALS, INC. (US) | 2014-05-30 | — | — | WO | disclosed |
| EP-2504008-A1 | METHODS AND ASSAYS FOR THE TREATMENT OF IRRITABLE BOWEL SYNDROME | Lexicon Pharmaceuticals, Inc. (US) | 2012-10-03 | — | — | EP | disclosed |
| WO-2011063181-A1 | METHODS AND ASSAYS FOR THE TREATMENT OF IRRITABLE BOWEL SYNDROME | LEXICON PHARMACEUTICALS, INC. (US) | 2011-05-26 | — | — | WO | disclosed |